Design and synthesis of some pyridazine containing compounds of expected anticancer activity / (Record no. 62405)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 03479cam a2200349 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223031809.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 170919s2017 ua d f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.08.04.Ph.D.2017.De.D |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Demiana Samir Mikhail |
| 245 10 - TITLE STATEMENT | |
| Title | Design and synthesis of some pyridazine containing compounds of expected anticancer activity / |
| Statement of responsibility, etc. | Demiana Samir Mikhail ; Supervised Salwa Elsayed Mohamed Elmeligie , Eman Mohamed Ahmed , Suzan Mohamed Abuelmaaty |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | {uFE97}{uFEBC}{uFEE4}{uFBFF}{uFEE2} و {uئإ٩٧}{uئإآ٨}{uئإئ٤}{uئآئئ}{uئإءء} {uئإ٩١}{uئإأأ}{uئإآإ} المر{uئإؤآ}{uئإ٩٢}{uئإ٨إ}ت {uئإ٨ؤ}{uئإؤئ}{uئإ٩٨}{uئإئ٠} {uئإ٩٧}{uئإء٤}{uئإ٩٨}{uئإإإ}{uئإإئ} {uئإأآ}{uئإإ٠}{uئإئ٠} {uئإء٣}{uئإإ٠}{uئإؤ٨}{uئإ٩٤} {uئإ٨ؤ}{uئإؤئ}{uئإ٩٢}{uئآئئ}{uئإءإ}{uئآئإ}{uئإءء}از{uئآئإ}{uئإإ٦} {uئإإؤ} {uئإ٨ؤ}{uئإؤئ}{uئإإ٤}{uئإ٩٨}{uئإإإ}{uئإؤ٧}{uئإأء} {uئإؤئ}{uئإإأ}{uئإ٨إ} {uئإ٩٧}{uئإ٨٤}{uئإ٩آ}{uئآئئ}{uئإءإ} {uئإإ٣}{uئإأ٠}{uئإ٨إ}{uئإء٩} {uئإؤئ}{uئإإ٠}{uئإآ٤}{uئإءإ}ط{uئإ٨إ}ن |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Demiana Samir Mikhail , |
| Date of publication, distribution, etc. | 2017 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 142 P. : |
| Other physical details | charts ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Organic Chemistry |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | This study comprises a brief literature survey on cancer, its causes and treatment as well as biological activities and chemistry of pyridazine and fused pyridazine derivatives. The thesis involves design of some new pyridazine and fused pyridazine derivatives aiming to possess an anticancer activity through inhibition of VEGFR. The Schemes followed for the preparation of the designed compounds are summarized asfollows: Scheme (1) starts with the preparation of the root compound N-carbamimidoyl-4-[(6-chloropyridazin-3-yl) amino]benzenesulphonamide (I) followed by reaction with different aromatic amines to give N-Carbamimidoyl-4- [(6-arylaminopyridazin-3-yl)amino]benzenesulphonamides IIa-f. Scheme (2) involves nucleophilic substitution reaction of compound I with meta and para phenylenediamine to give the relevant compounds IIIa, b. Furthermore, compound IIIa was reacted with each of acetyl chloride and 3-chloropropionyl chloride to give the corresponding pyridazine derivatives IVa, b respectively. Further, compounds IIIa, b were reacted with different alkyl isothiocyanates to give the corresponding thiourea compounds Va-d and VIa-d. On the other hand, scheme (3A) involves the reaction of compound I with each of 2-aminophenol, different substituted anthranilic acids and 2-aminonicotinic acid to give the corresponding pyridazino [1,6-a] benzimidazole VII, pyridazino [6,1-b] quinazolines VIIIa,c,d and pyrido [2{u2019}, 3{u2019},4,5] pyrimido [1,2- b]pyridazine VIIIb respectively |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Anticancer activity |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Cancer |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Pyridazine |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Eman Mohamed Ahmed , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Salwa Elsayed Mohamed Elmeligie , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Suzan Mohamed Abuelmaaty , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Samia |
| Reviser | Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.08.04.Ph.D.2017.De.D | 01010110072731000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.08.04.Ph.D.2017.De.D | 01020110072731000 | 22.09.2023 | CD - Rom | 72731.CD |