Design, synthesis and evaluation of fused pyrimidine derivatives as potential anticancer agents / (Record no. 62417)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 03366cam a2200349 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223031809.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 170919s2017 ua f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.08.04.Ph.D.2017.Ya.D |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Yara Sayed Mahmoud Eldash |
| 245 10 - TITLE STATEMENT | |
| Title | Design, synthesis and evaluation of fused pyrimidine derivatives as potential anticancer agents / |
| Statement of responsibility, etc. | Yara Sayed Mahmoud Eldash ; Supervised Samir Botros Salib , Omneya Mahmoud Khalil , Mona Mounir Kamel |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | {uFE97}{uFEBC}{uFEE4}{uFBFF}{uFEE2} و {uئإ٩٧}{uئإآ٨}{uئآئئ}{uئآئئ}{uئإءء} و {uئإ٩٧}{uئإؤ٨}{uئآئئ}{uئآئئ}{uئإإ٢} {uئإإ٣}{uئإآ٨}{uئإ٩٨}{uئإؤ٨}{uئإ٨إ}ت {uئإء٣}{uئإإ٠}{uئإؤ٨}{uئإ٩٤} ا{uئإؤئ}{uئإ٩٢}{uئآئئ}{uئإءإ}{uئآئإ}{uئإإ٤}{uئآئئ}{uئإءء}{uئآئإ}{uئإإ٦} ا{uئإؤئ}{uئإإ٤}{uئإإ٠}{uئإ٩٨}{uئإء٤}{uئإإ٤}{uئإ٩٤} {uئإؤآ}{uئإإ٤}{uئإأ٠}{uئإ٨إ}دات {uئإؤئ}{uئإإ٠}{uئإآ٤}{uئإءإ}ط{uئإ٨إ}ن |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Yara Sayed Mahmoud Eldash , |
| Date of publication, distribution, etc. | 2017 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 274 P. ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Organic Chemistry |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | The present Thesis comprises six chapters and aims at the synthesis and evaluation of the anticancer activity of a number of tetrahydrobenzothieno [2,3-d] pyrimidines as well as tetrahydrobenzothieno [3,2-e][1,2,4] triazolo [4,3-a] pyrimidine derivatives. Chapter I is an introduction which consists of a brief literature survey on the recent approaches in the synthesis of thieno[2,3-d]pyrimidine derivatives and 1,2,4-triazolo[4,3-a]pyrimidines in addition to an account on their cytotoxic activity. Moreover, a brief account on matrix metalloproteinase inhibitors and their fundamental interactions with MMP binding sites is included. Chapter II presents the aim of the work together with illustration of the schemes carried out to obtain the new thieno [2,3-d]pyrimidine derivatives. Chapter III explains the theoretical discussion of the experimental work used for the synthesis of the newly synthesized compounds (schemes A-H) and spectroscopic confirmation of the intermediates and the target compounds. Scheme A is concerned with the preparation of the starting compound; ethyl 2- amino-4,5,6,7-tetrahydro[1] benzothiophene-3-carboxylate (I). Reaction of I with benzyl isothiocyanate yielded the key intermediate 3-benzyl-2-sulphanyl-5,6,7,8- tetrahydro-4-oxo(3H)-[1]benzothieno[2,3-d]pyrimidine (II). Alkylation of the 2- sulfanylthienopyrimidine II was carried out using different solvent/ base systems in order to obtain a series of S-alkylated derivatives VIa-d, VIIa-c and VIIIa-c which differ in the linker skeleton as well as the bioactive amine |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | 1,2,4-triazolothienopyrimidines |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Anticancer activity |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Thieno [2,3-d]pyrimidines |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Mona Mounir Kamel , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Omneya Mahmoud Khalil , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Samir Botros Salib , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Samia |
| Reviser | Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.08.04.Ph.D.2017.Ya.D | 01010110072734000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.08.04.Ph.D.2017.Ya.D | 01020110072734000 | 22.09.2023 | CD - Rom | 72734.CD |