Synthesis and biological evaluation of some new heterocycles incorporating pyridine / (Record no. 62826)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 03657cam a2200337 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223031822.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 171009s2016 ua h f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | M.Sc. |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.12.10.M.Sc.2016.Al.S |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Aly Hassan Abdelrahman Aly |
| 245 10 - TITLE STATEMENT | |
| Title | Synthesis and biological evaluation of some new heterocycles incorporating pyridine / |
| Statement of responsibility, etc. | Aly Hassan Abdelrahman Aly ; Supervised Fathy Mohamed Abdelrazek , Sobhy Mohamed Gomaa |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | تشييد وتقييم النشاط البيولوجى لبعض الحلقيات الغير متجانسة الجديدة المحتوية على بيريدين |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Aly Hassan Abdelrahman Aly , |
| Date of publication, distribution, etc. | 2016 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 160 P. : |
| Other physical details | facsimiles ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (M.Sc.) - Cairo University - Faculty of Science - Department of Organic Chemistry |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | In the first part: A novel series of 2-ethylidenehydrazono-5-arylazothiazoles 5a-h and 2-ethylidenehydrazono-5- arylazothiazolones 9a-d were prepared by cyclocondensation of hydrazonyl halides 3a-h and 7a-d with ethylidenethiosemicarbazide 2. In addition, reaction of 2 with N-phenyl carbohydrazonyl chloride (14), afforded 1,3,4-thiadiazole derivative 17 as the end product. Moreover, the thiosemicarbazide derivative 2 was reacted with various bromoacetyl compounds 19a-d and 1,1'-(1,4-phenylene)bis(2-bromoethanone) (21) furnished the respective thiazole derivatives 20a-d and 1,4-phenylene-bis-thiazole derivative 22. The structures of the newly synthesized compounds were established on the basis of spectroscopic evidences and their alternative syntheses. The newly synthesized compounds were evaluated for their anti-tumor activities against hepatocellular carcinoma (HepG2) cell line and the results revealed promising activities of compounds 5h, 5d, 5g, 5f and 5e with IC50 equal 2.23 ± 0.28, 2.48 ± 0.34, 2.49 ± 0.24, 4.03 ± 0.11, and 5.32 ± 0.27 oM, respectively. In the second part: (E)-3-(Dimethylamino)-1-(pyridin-4-yl)prop-2-en-1-one 2 underwent regioselective 1,3-dipolar cycloaddition with nitrilimines 4 to afford the corresponding pyrazoles 6. The reaction of the latter pyrazoles with hydrazine hydrate, afforded the corresponding pyrazolo[3,4-d]pyridazines 7. The enaminone 2 reacts also with 6- aminothiouracil 8 to yielded respective thione 9. The reaction of thione 9 with hydrazonoyl chlorides 3 yielded pyrido[2,3-d][1,2,4]triazolo[4,3-a]pyrimidinone derivatives 13. Furthermore, pyridine analogs substituted in the 4- position with a pyranone 17 or pyridinones 18, pyridinone 20, 22 or naphthofuran 24 were also synthesized. The structures of the newly synthesized compounds were confirmed by spectral data and elemental analyses. The antimicrobial activity of these newly synthesized compounds were assayed against two fungi species and two bacterial species; one Gram positive and one gram negative. Compounds 24 and 18 showed the most inhibitory effect among all tested compound. Molecular docking study predicted the best binding mode between compound 24 and the Enoyl-[acyl-carrier-protein] reductase [NADH] (InhA)f the compounds exhibit considerable activities |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Heterocycles incorporating pyridine |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Incorporating pyridine |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | New heterocycles |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Fathy Mohamed Abdelrazek , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Sobhy Mohamed Gomaa , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Shimaa |
| Reviser | Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.12.10.M.Sc.2016.Al.S | 01010110072971000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.12.10.M.Sc.2016.Al.S | 01020110072971000 | 22.09.2023 | CD - Rom | 72971.CD |