Evaluation of MicroRNA 27b and MicroRNA 137 as biomarkers of activity and malignant transformation in oral Lichen planus patients : (Record no. 63581)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 02547cam a2200349 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223031844.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 171120s2012 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.09.04.Ph.D.2012.Sa.E |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Sana Maher Aghbary |
| 245 10 - TITLE STATEMENT | |
| Title | Evaluation of MicroRNA 27b and MicroRNA 137 as biomarkers of activity and malignant transformation in oral Lichen planus patients : |
| Remainder of title | Clinical trial / |
| Statement of responsibility, etc. | Sana Maher Aghbary ; Supervised Soheir Mohamed Gaafar , Olfat Gamil Shaker , Shahira Gamal Elashiry |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | كموشرات حيوي للنشاط المرضى والتحول السرطانى في مرضى الحزاز الفموىmicroRNA137و microRNA27b تققيم |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Sana Maher Aghbary , |
| Date of publication, distribution, etc. | 2012 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 98 , (39) P. : |
| Other physical details | charts , facsimiles ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (Ph.D.) - Cairo University - Faculty of Oral and Dental Medicine - Department of Oral Pathology |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Oral lichen planus (OLP) is a chronic inflammatory muccocutaneous disease with a potential malignant transformation, characterized by cytotoxic T cell against basal epithelial cells. MicroRNAs (miRNAs) are a short non-coding RNA that plays a critical role in gene expression at post-transcriptional levels. Many evidence showed that miRNAs play an important role in regulating immune response and cancer development. The purpose of the present study to compare the expression of microRNA 27b and microRNA137 in tissues and saliva between OLP patients and controls, also, to evaluate their use as biomarkers of disease activity and malignant transformation by using real-time quantitative PCR. Our result showed down expression in miRNA27b and miRNA137 in tissue and saliva of OLP compared to control, denoting the role of miRNA27b and miRNA137 in the pathogenesis and potential malignant transformation of OLP. In conclusion, the down expression of salivary miRNA27b and miRNA137 favor the use of saliva sample as a noninvasive method for monitoring OLP activity and malignant transformation |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | MicroRNA 137 |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | MiRNA27b |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Oral lichen planus |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Olfat Gamil Shaker , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Shahira Gamal Elashiry , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Soheir Mohamed Gaafar , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Shimaa |
| Reviser | Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.09.04.Ph.D.2012.Sa.E | 01010110073349000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.09.04.Ph.D.2012.Sa.E | 01020110073349000 | 22.09.2023 | CD - Rom | 73349.CD |