Design, synthesis and biological evaluation of novel fused imidazo[4,5-b]pyridine derivatives as anticancer agents / (Record no. 64259)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 03175cam a2200349 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223031904.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 171226s2017 ua h f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | M.Sc |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.08.05.M.Sc.2017.Na.D |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Nada Mosallam Mohamed Ghanem Mosallam |
| 245 10 - TITLE STATEMENT | |
| Title | Design, synthesis and biological evaluation of novel fused imidazo[4,5-b]pyridine derivatives as anticancer agents / |
| Statement of responsibility, etc. | Nada Mosallam Mohamed Ghanem Mosallam ; Supervised Safinaz E. Abbas , Ossama M. Elbadry , Riham F. George |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | تصميم وتشييد وتقييم بيولوجي لمشتقات جديدة من الإيميداز و (4.5-ب) بيريدين كمضادات لمرض السرطان |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Nada Mosallam Mohamed Ghanem Mosallam , |
| Date of publication, distribution, etc. | 2017 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 135 P. : |
| Other physical details | facsimiles ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Pharmaceutical Chemistry |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Cancer represents a major health problem. Although there has been a progress in the treatment and prevention of cancer, this disease remains the second major cause of death after cardiovascular diseases in the world. Accordingly, continued research is needed to develop new antitumor agents. Imidazopyridine scaffold had considerable therapeutic activities in the treatment of different cancer types such as breast, colon, glioma, prostate, colorectal and lung through inhibition of cyclin-dependent kinase enzymes (CDKs). Therefore, novel imidazopyridine were designed and synthesized starting from 4- (1H-imidazo[4,5-b]pyridin-2-yl)aniline I either via preparation of the diethyl methylene malonate derivative II followed by cyclization to pyrazolidine III-V, pyrimidine VI-VII, triazepine derivative VIII or diazotization of the amino functionality of I followed by coupling with phenol, aniline or active methylene derivatives to afford IXa-f, X and XI, respectively. The cytotoxic activity of the synthesized compounds was investigated against two cell lines, namely: MCF-7 and HCT-116. Compounds showing promising activity were further evaluated for their CDK9 inhibitory activity where they exhibited remarkable activity. Furthermore, molecular docking of the tested compounds was established with the active site of CDK9 enzyme domain to investigate the possible binding mode between the synthesized compounds and the binding pocket in the active site of the enzyme. In conclusion, based on both in vitro cytotoxicity study and CDK9 enzyme assay, most of the synthesized compounds exhibited significant anti-proliferative and CDK9 inhibitory activity, which suggests that these compounds might possible act as CDK9 inhibitors |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Anticancer |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | CDK inhibitors |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Imidazo pyridine |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Ossama M. Elbadry , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Riham F. George , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Safinaz E. Abbas , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Shimaa |
| Reviser | Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.08.05.M.Sc.2017.Na.D | 01010110073894000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.08.05.M.Sc.2017.Na.D | 01020110073894000 | 22.09.2023 | CD - Rom | 73894.CD |