Oxidant {u2013}antioxidant status in sickle cell disease patients in relation to Trans-cranial Doppler (TCD) Velocities and Estimated Systolic Pulmonary Artery Pressure (ESPAP) / (Record no. 65661)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 03581cam a2200349 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223031950.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 180331s2017 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.11.28.Ph.D.2017.Ra.O |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Rasha Rady Mohamed Mohamed Ali |
| 245 10 - TITLE STATEMENT | |
| Title | Oxidant {u2013}antioxidant status in sickle cell disease patients in relation to Trans-cranial Doppler (TCD) Velocities and Estimated Systolic Pulmonary Artery Pressure (ESPAP) / |
| Statement of responsibility, etc. | Rasha Rady Mohamed Mohamed Ali ; Supervised Khaled Mohamed Salama , Mona Kamal Elghamrawy , Rodina Sobhy |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | الأكسدة ومضادات الأكسدة عند مرضى أنيميا الخلايا المنجلية و علاقتها بسرعة الدم فى شرايين المخ والضغط فى الشريان الرئوى |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Rasha Rady Mohamed Mohamed Ali , |
| Date of publication, distribution, etc. | 2017 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 131 P. : |
| Other physical details | charts , facsimiles ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Pediatrics |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Background: A Chronic pro-inflammatory state exists in sickle cell disease (SCD) patients, even in the clinically asymptomatic phase. In SCD patients, the relation between the chronic pro-inflammatory state and oxidative stress is bidirectional. Aim of work: Assessment of the oxidant {u2013}anti oxidant status in SCD patients in its relation to transcranial Doppler (TCD) velocities and estimated pulmonary artery pressure (ESPAP). Patients and Methods: This case-control study included 78 SCD patients (31 SS, 47 SB) in steady state as well as 40 age and sex matched healthy controls. Serum nitrite, malondialdhyde (MDA), paraoxinase (PON), catalase and total antioxidant capacity (TOA) were estimated calorimetrically.TCD was done via transtemporal approach according to STOP trial and pulmonary hypertension was assessed as an estimate from tricuspid regurge (TR) jet velocity using the modified Bernoulli equation. Results: Serum nitrite and serum MDA were significantly higher in cases than controls (P {u02C2}0.01, {u02C2}0.01, respectively) while serum catalase and serum PON and TOA were significantly lower in cases than controls (P=0.03, {u02C2}0.01, {u02C2}0.01, respectively). Serum nitrite showed significant negative correlation with TOA and serum catalase (P {u02C2}0.01, 0.03 respectively). Serum PON showed significant negative correlation with age of patient, age at 1st dose of hydroxyurea (HU) among all patients (P{u02C2}0.05,{u02C2}0.05 respectively).TOA significantly correlated to TCD velocities in right dICA among all patients and SB patients(P{u02C2}0.05, {u02C2}0.01 respectively). Among SS group, serum nitrite significantly correlated to Hb F (P{u02C2}0.05) while serum catalase showed statistically significant negative correlations with Hb F (P {u02C2}0.05). Among SB group, serum PON showed significant negative correlation with duration of chelation (P{u02C2}0.05) and significantly correlated to Hb F (P{u02C2}0.05). No correlation was found between all measured oxidants-antioxidants and ESPAP among our patients |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Oxidants |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | SCA |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Trans-cranial Doppler |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Khaled Mohamed Salama , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Mona Kamal Elghamrawy , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Rodina Sobhy , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Shimaa |
| Reviser | Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.11.28.Ph.D.2017.Ra.O | 01010110074719000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.11.28.Ph.D.2017.Ra.O | 01020110074719000 | 22.09.2023 | CD - Rom | 74719.CD |