Spotlight on early predictors of progressive multiple sclerosis : (Record no. 65905)
[ view plain ]
| 000 -LEADER | |
|---|---|
| fixed length control field | 03176cam a2200349 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223031957.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 180417s2017 ua h f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.11.20.Ph.D.2017.Re.S |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Rehab Magdy Hassan |
| 245 10 - TITLE STATEMENT | |
| Title | Spotlight on early predictors of progressive multiple sclerosis : |
| Remainder of title | Neuro-cognitive, genetic and optical coherence tomography studies / |
| Statement of responsibility, etc. | Rehab Magdy Hassan ; Supervised Maged Mohammed Abdelnaseer , Shereen Fathi Sheir , Nagwa Kamal Eldin Roshdy |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | إلقاء الضوءعلى تنبؤات مبكرة للتصلب المتعدد التقدمى : |
| Remainder of title | دراسة الوظائف المعرفية: و الصفات الوراثية و التصويرالمقطعى للتماسك البصرى |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Rehab Magdy Hassan , |
| Date of publication, distribution, etc. | 2017 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 194 P. : |
| Other physical details | facsimiles ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Neurosurgery |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Identification of MS patients with a high risk for progression has been a challenge for decades. Objective: To determine the role of neuro-cognitive, genetic and optical coherence tomography (OCT) on multiple sclerosis (MS) disease progression. Subjects and methods: Two groups of definite MS patients, relapsing remitting multiple sclerosis (RRMS) and secondary progressive multiple sclerosis (SPMS), each with 25 patients, were submitted to a battery of neuropsychological tests, OCT and glutamate N-methyl-D-aspartate receptors (NMDARs) gene studies. Results: The best predictor for progressive MS is SDMT (symbol digit modality test) (P value 0.021), that is dependent statistically on the educational level of the MS patient (P value 0.016). The most specific and sensitive test in discrimination between RRMS and SPMS groups is provided through OCT via thickness of average RNFL (retinal nerve fiber layer). Eighty three percent of MS patients with CC genotype reported frequent previous attacks of optic neuritis with significant marked thinning in RNFL and GCC (ganglion cell complex) despite of their higher cognitive performance in comparison to other genotypes. Conclusions: An early deficit in information processing speed measured by SDMT is a good predictor of early transition to SPMS. Thicknesses of RNFL of 83.65om and GCC of 77.47om are indications for induction therapy to prevent transitioning to secondary progressive phase with high sensitivity; 91.7% and 87.5% respectively. Finally, presence of CC genotype of glutamate NMDARs gene predicts frequent optic neuritis episodes with marked visual loss, although the same genotype may preserve cognitive functions |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Multiple sclerosis |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Optic neuritis |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | SDMT |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Maged Mohammed Abdelnaseer , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Nagwa Kamal Eldin Roshdy , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Shereen Fathi Sheir , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Samia |
| Reviser | Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.11.20.Ph.D.2017.Re.S | 01010110074912000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.11.20.Ph.D.2017.Re.S | 01020110074912000 | 22.09.2023 | CD - Rom | 74912.CD |