Assessment of DNA damage and oxidative stress in some pesticides-exposed agricultural workers with GSTP1 and XRCC1 genes polymorphisms / (Record no. 66250)
[ view plain ]
| 000 -LEADER | |
|---|---|
| fixed length control field | 03291cam a2200349 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223032007.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 180519s2017 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.12.21.Ph.D.2017.Eb.A |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Ebtesam Abdelrashid Abdelshafy Badawy |
| 245 10 - TITLE STATEMENT | |
| Title | Assessment of DNA damage and oxidative stress in some pesticides-exposed agricultural workers with GSTP1 and XRCC1 genes polymorphisms / |
| Statement of responsibility, etc. | Ebtesam Abdelrashid Abdelshafy Badawy ; Supervised Magda M. Noshy , Haidan M. Salem , Amal Saad Hussien |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | XRCC1 و GSTP1 تقييم تلف الحمض النووي والإجهاد التاكسدي فى عمال الزراعة المعرضين لبعض المبيدات مع تعدد أشكال الجينات |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Ebtesam Abdelrashid Abdelshafy Badawy , |
| Date of publication, distribution, etc. | 2017 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 96 P. : |
| Other physical details | charts , facsimiles ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (Ph.D.) - Cairo University - Faculty of Science - Department of Zoology |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Pesticides exposure has been proved to be associated with elevated risk of genotoxicity and carcinogenicity. Previous studies have indicated that genetic polymorphism in GSTP1 gene that encoded proteins involved metabolism/detoxification may modulate pesticides metabolism. On the other hands, genetic polymorphism in XRCC gene that encoded proteins involved in DNA repair process may influence pesticides genotoxicity. Thus, we investigated whether various metabolic (GSTP1) and DNA repair (XRCC1) genotypes could increase the risk of DNA damage and oxidative stress in pesticides-exposed agricultural workers. The different genotypes of studied genes were identified by PCRRFLP technique. The DNA damage was estimated using comet assay. Moreover, oxidative stress and antioxidant status of pesticides-exposed agricultural workers were evaluated relative to control subjects. In this study, measurement of cholinesterase activity was used as a biomarker for pesticides exposure. The results of the present work showed that individuals carrying GSTP1 Ile-Ile or XRCC1 399 Arg-Arg genotypes are more susceptible to DNA damage and could be at high risk of cancer. Moreover, there was an alteration in antioxidant status and significant increase in oxidative stress biomarker (MDA) in pesticides-exposed agricultural workers compared to unexposed controls. In addition, there was positive correlation between oxidative stress marker (MDA) and DNA damage. In conclusion, our study indicated that polymorphism in GSTP1 and XRCC1 genes could modulate extent of DNA damage caused by pesticides exposure. The susceptible workers agricultural workers who are involved in pesticides handling should be provided with more protective equipments in order to reduce the potential hazard of occupational exposure to these carcinogenic agents |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | AChE |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | BuChE |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | pesticides |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Amal Saad Hussien , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Haidan M. Salem , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Magda M. Noshy , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Shimaa |
| Reviser | Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.12.21.Ph.D.2017.Eb.A | 01010110075052000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.12.21.Ph.D.2017.Eb.A | 01020110075052000 | 22.09.2023 | CD - Rom | 75052.CD |