Study the correlation between tumor necrosis factor Alpha (TNF-Ü) gene polymorphism and the development of FVIII inhibitors In Egyptian hemophilia a patients / (Record no. 68813)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 03407cam a2200349 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223032125.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 181129s2018 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | M.Sc |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.11.18.M.Sc.2018.Da.S |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Dalia Mohamed Mohamed Abdelrhman |
| 245 10 - TITLE STATEMENT | |
| Title | Study the correlation between tumor necrosis factor Alpha (TNF-Ü) gene polymorphism and the development of FVIII inhibitors In Egyptian hemophilia a patients / |
| Statement of responsibility, etc. | Dalia Mohamed Mohamed Abdelrhman ; Supervised Alia Abdelaziz Saad Ayad , Hoda Ali Sadek , Doaa M. Eldemerdash |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | دراسة العلاقة بين تعدد الشكل الجيني لعامل نخر الورم ألفا و تكون مثبطات عامل التجلط الثامن في المرضى المصريين المصابين بهيموفيليا ألف |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Dalia Mohamed Mohamed Abdelrhman , |
| Date of publication, distribution, etc. | 2018 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 148 P. : |
| Other physical details | charts , facsimiles ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Internal Medicine |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Background : The development of alloantibodies (inhibitors) against the transfused factor VIII in Hemophilia A patients is the most serious therapy complication. The pathophysiology of their formation is still unknown. Many cytokines, including tumor necrosis factor-Ü (TNF-Ü), may play a role in the perpetuation of such complication. Aim of the Work: The aim of this study is to evaluate the influence of TNF-Ü gene polymorphism (308G/A) on the development of FVIII inhibitors. Also, the effects of some treatment related risk factors of the formation of FVIII inhibitors in multi-transfused hemophilia A patients.Patients and methods: Fifty patients with moderate to severe hemophilia A were examined for existence of FVIII inhibitors by Bethesda method, and classified into 25 patients positive inhibitor group and 25 patients negative inhibitor group. In addition, all the patients, were genotyped for TNF-Ü gene polymorphisms (308G/A) using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Chi square test and Fisher{u2019}s exact test were used for statistical analysis. Results: The 25 patients developed FVIII inhibitors, 19 patients (76%) had low titer (< 5 BU/ml) and 6 patients (24%) had high titer (> 5BU/ml). The studied treatment related risk factors has no relation with FVIII inhibitor development. No statistically significant correlation was found between the positivity of anti FVIII antibodies and the TNF-Ü gene polymorphism (308A/G) (P =0.426). The difference between positive inhibitor group and negative inhibitor group regarding the genotype frequency of TNF-Ü (308A/G) is not statistically significant (P = 0.083). We did not find a significant correlation between the existence of such polymorphism and any of the studied treatment related risk factors |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | FVIII inhibitors |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Hemophilia A |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | TNF-Ü (308A/G) gene polymorphism |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Alia Abdelaziz Saad Ayad , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Doaa Mohamed Eldemerdash , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Hoda Ali Sadek , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Enas |
| Reviser | Cataloger |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.11.18.M.Sc.2018.Da.S | 01010110076484000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.11.18.M.Sc.2018.Da.S | 01020110076484000 | 22.09.2023 | CD - Rom | 76484.CD |