Role of epigenetic changes in the pathogenesis, prognosis and management of hematopoietic malignancies / (Record no. 69392)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 02740cam a2200337 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223032143.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 190103s2018 ua h f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | M.Sc |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.11.18.M.Sc.2018.Na.R |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Nawal Eltayeb Omer Mohamed |
| 245 10 - TITLE STATEMENT | |
| Title | Role of epigenetic changes in the pathogenesis, prognosis and management of hematopoietic malignancies / |
| Statement of responsibility, etc. | Nawal Eltayeb Omer ; Supervised Mona Mohammad Elkassas , Asmaa Mohammad Abdelhameed |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | دور التخلق المتوالى فى تخليق سرطانات الدم و التكهن بمالآتها و علاجها |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Nawal Eltayeb Omer Mohamed , |
| Date of publication, distribution, etc. | 2018 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 141 P. : |
| Other physical details | facsimiles ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Internal Medicine |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Background: Hematopoietic malignancies are among the top ten cancers worldwide, despite the progress that has been made in the treatment of hematologic malignancies overall survival rates are still low and most patients still have a shorter lifespan. In recent years, accumulating data appreciate the role of epigenetics in the pathogenesis of hematologic malignancies. Objectives: Our objective was to search the literature about the role of epigenetic changes in pathogenesis and prognosis of hematologic malignancies and see how understanding of this role can be used for better management of hematologic malignancies. Methods: We comprehensively reviewed electronic databases including google, google scholar, PubMed and cochrane lLibrary about the role of epigenetic changes in hematologic malignancies. Results and conclusion: Epigenetic changes play a fundamental role in pathogenesis of hematologic malignancies. Mutations involving epigenetic regulating genes like DNMTs, TET1/2, EZH2, IDH1/2 and ASXL1 recurrently occur in hematologic malignancies and sometimes these mutations represent the drive event in the development of hematologic malignancies. Presence of these changes in hematologic malignancies indicates poor prognosis, epigenetic drugs are very promising in treating hematologic malignancies. More researches in this field hopefully will lead to production of more efficient treatments for hematologic malignancies |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Cancer |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Epigenetics |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Hematologic malignancies |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Asmaa Mohammad Abdelhameed , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Mona Mohammad Elkassas , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Samia |
| Reviser | Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.11.18.M.Sc.2018.Na.R | 01010110076704000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.11.18.M.Sc.2018.Na.R | 01020110076704000 | 22.09.2023 | CD - Rom | 76704.CD |