Synthesis of novel oxadiazole and chromene derivatives as cytotoxic agents / (Record no. 69771)
[ view plain ]
| 000 -LEADER | |
|---|---|
| fixed length control field | 02153cam a2200349 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223032154.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 190127s2018 ua d f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | M.Sc |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.08.04.M.Sc.2018.Ne.S |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Nehal Mohamed Nabil Elbakhshawangy |
| 245 10 - TITLE STATEMENT | |
| Title | Synthesis of novel oxadiazole and chromene derivatives as cytotoxic agents / |
| Statement of responsibility, etc. | Nehal Mohamed Nabil Elbakhshawangy ; Supervised Azza Taher Taher Shalaby , Hala Bakr Ali Elnassan , Asmaa Elsayed Abdellatief Kassab |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | تشييد مشتقات جديدة من الأوكساديازول و الكرومين كمضادات للأورام |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Nehal Mohamed Nabil Elbakhshawangy , |
| Date of publication, distribution, etc. | 2018 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 140 P. : |
| Other physical details | charts ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Organic Chemistry |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | The design and synthesis of 1,3,4-oxadiazoles and chromenopyrimidines as microtubule destabilizing agents has been explained. The newly synthesized compounds were evaluated for their cytotoxicity against MCF-7 cell line. All the prepared chromenopyrimidines showed potent cytotoxic activity. Compound XVb was the leading compound as it showed IC₅₀ values of 0.13 oM on tumor cell line MCF-7 (11-fold more active than the reference drug colchicine) and 14.06 oM on mammary epithelial cell line MCF-10A. Also, it inhibited tubulin polymerization (IC₅₀ = 8.36oM), caused cell cycle arrest at G2/M phase (five folds more than control) and cellular apoptosis. Moreover, it increased the level of active caspase-3, 12-fold compared with control. |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Chromene derivatives |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Cytotoxic agents |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Novel oxadiazole |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Asmaa Elsayed Abdellatief Kassab , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Azza Taher Taher Shalaby , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Hala Bakr Ali Elnassan , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Shimaa |
| Reviser | Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.08.04.M.Sc.2018.Ne.S | 01010110076992000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.08.04.M.Sc.2018.Ne.S | 01020110076992000 | 22.09.2023 | CD - Rom | 76992.CD |