Evaluation of adipose derived stem cell therapy in a canine model of multiple sclerosis / (Record no. 71696)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 03248cam a2200349 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223032251.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 190424s2018 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.10.13.Ph.D.2018.Ah.E |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Ahmed Nour Eldine Abdallah |
| 245 10 - TITLE STATEMENT | |
| Title | Evaluation of adipose derived stem cell therapy in a canine model of multiple sclerosis / |
| Statement of responsibility, etc. | Ahmed Nour Eldine Abdallah ; Supervised Ashraf Aly Eldesoky Shamaa , Omar Mohammed Salah Eldin Eltookhy , Momtaz Abdelhady Shahin |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | تقييم الخلايا الجذعية المستخلصة من النسيج الدهني في علاج التصلب المتعدد المستحدث تجريبياً في الكلاب |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Ahmed Nour Eldine Abdallah , |
| Date of publication, distribution, etc. | 2018 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 139 P. : |
| Other physical details | charts , facsimiles ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (Ph.D.) - Cairo University -Faculty of Veterinary Medicine - Department of Surgery -Anesthesiology and Radiology |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Multiple sclerosis (MS) is a chronic, inflammatory, demyelinating disease of the central nervous system, whose etiology remains unknown. MS destroys oligodendrocytes, which are the cells responsible for creating and maintaining the myelin sheath, which helps the neurons carry electrical signals. This work aimed to evaluate the treatment of experimentally induced MS in dogs using laser activated adipose derived stem cells. Twenty-four animals were used in study divided into 2 main groups. All animals received bilateral intraspinal injection of 20 æl of 0.1 % Ethidium bromide in the lateral columns using a microneedle syringe attached to a capillary tube through a drilled hole at the first lumbar vertebra. Treatment using prepared Stem cell preparation was applied by injection of (10 X106 nucleated cells) directly in the CSF at the day 14 from the induction of the MS. Results showed amelioration of the clinical signs over time confirmed by the resolution of the previous lesions on MRI. Histopathology showed that injecting stem cells directly into the CSF lead to positive migration of the cells and homing into the site of the lesion as confirmed by PKH26 stain. Therapy lead to marked inhibition of apoptic activity, decreasing inflammation and glial scar formation, regeneration of the destructed axons, remyelination of the lost myelin as detected by increasing of Myelin Basic Proteins and differentiated into oligodendrocyte progenitors expressing Olig2 marker. The electron microscopy showed the remyelination sequence till forming a dense myelin sheath around the axons. From the forementioned results we concluded that treatment using laser activated stem cells holds a promising therapeutic option for treatment of MS |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Demyelination |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Multiple sclerosis |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Spinal cord |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Ashraf Aly Eldesoky Shamaa , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Momtaz Abdelhady Shahin , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Omar Mohammed Salah Eldin Eltookhy , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Shimaa |
| Reviser | Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.10.13.Ph.D.2018.Ah.E | 01010110077954000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.10.13.Ph.D.2018.Ah.E | 01020110077954000 | 22.09.2023 | CD - Rom | 77954.CD |