Phytochemical study of certain plants growing in Egypt from family lamiaceae with anticholinesterase activity / (Record no. 71767)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 03164cam a2200337 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223032254.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 190504s2018 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | M.Sc |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.08.07.M.Sc.2018.Ta.P |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Tarek Ahmed Mokhtar Hussain Gadelhak |
| 245 10 - TITLE STATEMENT | |
| Title | Phytochemical study of certain plants growing in Egypt from family lamiaceae with anticholinesterase activity / |
| Statement of responsibility, etc. | Tarek Ahmed Mokhtar Hussain Gadelhak ; Supervised Soad Hanna Tadros , Mohamed Nabil Khalil |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | دراسة فيتوكيميائية لبعض النباتات التي تنمو في مصر من العائلة الشفوية والمثبطه لنشاط انزيم اسيتيل كولين استيريز |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Tarek Ahmed Mokhtar Hussain Gadelhak , |
| Date of publication, distribution, etc. | 2018 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 167 P. : |
| Other physical details | charts , facsimiles ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Pharmacognosy |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Many herbal preparations had showed efficacy in ameliorating Alzheimer`s disease (AD) as Lamiaceous plants. Among these, Salvia officinalis (Sage), Lavandula angustifolia (English Lavender) and Lavandula pubescens, growing in Egypt, were chemically profiled as per constituents of their volatile oils and alcoholic extracts. Furthermore, they were assessed for their cholinesterase inhibitory and antioxidant activities using Ellman's method and DPPH assay, respectively.GC/MS analysis of the hydrodistilled volatile oil of the three chosen plants revealed that (z)-thujone (32%), eucalyptol (65%) and carvacrol (32%) were the major components of the volatile oils of S. officinalis, L.angustifolia and L.pubescens, respectively.Chemical profiling of their alcoholic extracts using LC-DAD-MS/MS (negative mode) had showed their richness in phenolic acids (5, 8, 11), flavonoids(13, 6, 10) and diterpenoids(15,3); no diterpenoids were detected in L. pubescens. The investigated samples had comparable content of total phenolic (81.666 ± 0.134, 84.069 ±0.001, 70.116 ± 0.001) æg of gallic acid/mg of sample, while their total flavonoid content was (37.322 ± 0.049, 26.610 ±0.085, 44.116 ± 0.08) æg of quercetin/mg of sample respectively. In vitro biological investigation revealed that L. pubescens extract and Lavander oil showed higher anticholinesterase activity with IC50 0.53 ±0.16 (mg/ml), 0.49±0.015 (mg/ml) respectively compared to eserine and donepezil reference standards IC50 0.73 ±0.05374 (mg/ml), 0.092±0.001414 (mg/ml) respectively. L. pubesens extract and Lavander oil showed moderate antioxidant activity (IC50 0.21 ± 0.01mg/ml), (IC50 36.49 ± 1.8 mg/ml) respectively compared to gallic acid reference standard with IC50 0.009 ± 0.001mg/ml |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Alzheimer |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Lamiaceae |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Salvia |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Mohamed Nabil Khalil , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Soad Hanna Tadros , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Shimaa |
| Reviser | Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.08.07.M.Sc.2018.Ta.P | 01010110077971000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.08.07.M.Sc.2018.Ta.P | 01020110077971000 | 22.09.2023 | CD - Rom | 77971.CD |