Assessment of serum level of programmed death 1 (PD1) in pemphigus vulgaris / (Record no. 71990)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 02797cam a2200349 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223032301.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 190516s2018 ua h f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | M.Sc |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.11.10.M.Sc.2018.Sh.A |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Shimaa Khalifa Ali Khalifa |
| 245 10 - TITLE STATEMENT | |
| Title | Assessment of serum level of programmed death 1 (PD1) in pemphigus vulgaris / |
| Statement of responsibility, etc. | Shimaa Khalifa Ali Khalifa ; Supervised Ola Mohammad Mohammad Abu Zied , Nanis Abdelaleem Ragab , Laila Ahmed Rashed |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | تقييم مستوى عامل موت الخلايا المبرمج 1 فى مصل الدم فى مرض ذو الفقاع |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Shimaa Khalifa Ali Khalifa , |
| Date of publication, distribution, etc. | 2018 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 88 P. : |
| Other physical details | facsimiles ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Dermatology and Venerology |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Background: Pemphigus vulgaris is a life-threatening autoimmune blistering disease targeting the skin and mucous membranes caused by anti-desmoglein IgG autoantibodies that {uFB01}nally lead to acantholysis presenting clinically as progressive blistering. Programmed death 1 (PD-1) is an immune checkpoint that binds to two ligands, PD-L1 and PD-L2 that negatively regulates antigen receptor singling and play a critical role in the immunoregulation of autoimmune diseases. Aim of work: Assessment of serum levels of sPD1 in pemphigus vulgaris patients, and its correlation with clinical severity. Methods: Sixty pemphigus vulgaris patients (30 clinically active and 30 in a clinical remission) and thirty age matched healthy control subjects were included. Full clinical examination was done. For pemphigus patients, severity was measured by PDAI score. Serum levels of sPD1 were measured by ELISA for both patients and healthy control. Results: The level of serum sPD1 was significantly lower in patients than in controls (P<0.001) and significantly lower in active group than remission group (P<0.001). A correlation was done between serum PD1 and severity of pemphigus (PDAI), It revealed a statistically significant negative correlation with PDAI; (P<0.001, r=-0.4). Association between PDAI and mucosal affection revealed that PDAI was statistically significant higher in patients with a mucosal affection (p = 0.001) |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Pemphigus vulgaris |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Programmed cell death 1 |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Tolerance |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Laila Ahmed Rashed , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Nanis Abdelaleem Ragab , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Ola Mohammad Mohammad Abu Zied , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Samia |
| Reviser | Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.11.10.M.Sc.2018.Sh.A | 01010110077885000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.11.10.M.Sc.2018.Sh.A | 01020110077885000 | 22.09.2023 | CD - Rom | 77885.CD |