Decellularization of cancerous and fibrotic liver with the possibility of using the resultant matrix as a biological scaffold in liver tissue engineering through stem cell seeding / (Record no. 72575)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 02963cam a2200349 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223032320.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 190625s2019 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.12.21.Ph.D.2019.Mo.D |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Mohamed Shaaban Mohamed Salim |
| 245 10 - TITLE STATEMENT | |
| Title | Decellularization of cancerous and fibrotic liver with the possibility of using the resultant matrix as a biological scaffold in liver tissue engineering through stem cell seeding / |
| Statement of responsibility, etc. | Mohamed Shaaban Mohamed Salim ; Supervised Aliaa Mahmoud Issa , Hala Gabr Metwally , Abdelrazek Hussien Farrag |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | النزع الخلوى للكبد المسرطن والكبد المتليف وإمكانية إستخدام المصفوفة الكبدية الناتجة كهيكل بيولوجى فى الهندسة النسيجية للكبد من خلال زرع الخلايا الجزعية |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Mohamed Shaaban Mohamed Salim , |
| Date of publication, distribution, etc. | 2019 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 122 P. : |
| Other physical details | charts , facsimiles ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (Ph.D.) - Cairo University - Faculty of Science - Department of Zoology |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | This research aimed at studying the decellularization of normal, cancerous and fibrotic liver, the quality of the resulting liver matrix and finally the possibility of using the obtained liver matrix as a biological scaffold (bioscaffold) that could be used in liver tissue engineering. Three animal model groups, normal, hepatocellular carcinoma (HCC) and hepatic fibrosis (HF) were used in this study. Decellularization of livers from the three animal models (normal, HCC, HF) were done by detergent perfusion through the portal vein and the remaining extracellular matrix (bioscaffold) was examined through growth architecture, histological, DNA concentration, immunohistochemical and morphometric studies. The recorded data revealed the removal of more than 95% of the whole cell population of liver leaving its whole architecture with most important component of the extracellular matrix intact. Cubic fragments of the resulting decellularized liver bioscaffolds of the three animal models (normal, HCC, HF) were seeded (recellularized) with mesenchymal stem cells and the development of the seeded cells was examined through histological, DNA concentration and albumin concentration studies. The obtained data revealed the potential of the seeded cells to proliferate and differentiate into hepatic cells which could carry out their function |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Bioscaffold |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Collagen |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Decellularization |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Abdelrazek Hussien Farrag , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Aliaa Mahmoud Issa , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Hala Gabr Metwally , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Asmaa |
| Reviser | Cataloger |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.12.21.Ph.D.2019.Mo.D | 01010110078515000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.12.21.Ph.D.2019.Mo.D | 01020110078515000 | 22.09.2023 | CD - Rom | 78515.CD |