Enhancement of drug targeting using nanocarriers / (Record no. 74236)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 02239cam a2200349 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223032409.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 190929s2019 ua d f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | M.Sc |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.12.04.M.Sc.2019.Ra.E |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Raghda Adel Abdelbadia Mohamed Elshenawy |
| 245 10 - TITLE STATEMENT | |
| Title | Enhancement of drug targeting using nanocarriers / |
| Statement of responsibility, etc. | Raghda Adel Abdelbadia Mohamed Elshenawy ; Supervised Wael Mohy Edin Elshemey , Heba Mohamed Fahmy , Mohamed Mahmoud Fathy |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | تحسين توجيه الأدوية عن طريق الحاملات النانومترية |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Raghda Adel Abdelbadia Mohamed Elshenawy , |
| Date of publication, distribution, etc. | 2019 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 89 P. : |
| Other physical details | charts ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (M.Sc.) - Cairo University - Faculty of Science - Department of Biophysics |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Nowadays, Nanotechnology is used to solve the problem of the delivery of pharmaceuticals to the brain which is restricted by the blood brain barrier. In this study we prepared silica nanoparticles (MSNs) for deliver. Thymoquinone (TQ), which used as a drug model. The prepared nanoparticles were examined using TEM, DLS, and Zeta potential. TEM revealed that the size of prepared nanoparticle was about80-120nm, which was confirmed using Dynamic light scattering (DLS) measurements. Zeta potential measurements were 30.8±2.34 mV for free silica nanoparticles and - 15.9±1.85 mV for loaded with TQ. Assessment the TQ distribution in different brain areas showed that the nano-carrier enhance the targeting of TQ to the brain by 13.24%, 11.47%, 19.88% and 70.78%than free TQ in cortex, thalamus, midbrain and hypothalamus respectively. In conclusion: The using silica nanoparticlese increase the drug bioavailability to the brain |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Brain |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Silica nanoparticles |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Thymoquinone |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Heba Mohamed Fahmy , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Mohamed Mahmoud Fathy , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Wael Mohy Eldin Elshemey , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Samia |
| Reviser | Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.12.04.M.Sc.2019.Ra.E | 01010110079436000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.12.04.M.Sc.2019.Ra.E | 01020110079436000 | 22.09.2023 | CD - Rom | 79436.CD |