Correlation of pathogenic activity and disease severity in pemphigus vulgaris patients / (Record no. 75081)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 02795cam a2200349 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223032434.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 191111s2019 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | M.Sc |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.11.10.M.Sc.2019.Ay.C |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Ayat Mohamed Saleh Mohamed |
| 245 10 - TITLE STATEMENT | |
| Title | Correlation of pathogenic activity and disease severity in pemphigus vulgaris patients / |
| Statement of responsibility, etc. | Ayat Mohamed Saleh Mohamed ; Supervised Marwah Adly Mohamed Saleh , Solwan Ibrahim Elsamanoudy , Laila Ahmed Rashed |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | إرتباط النشاط الممرض بشدة المرض فى مرضى ذوالفقاع الشائع |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Ayat Mohamed Saleh Mohamed , |
| Date of publication, distribution, etc. | 2019 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 137 P. : |
| Other physical details | charts , facsimiles ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Dermatology and Venerology |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Background: Pemphigus vulgaris (PV) is a potentially fatal autoimmune blistering skin disease characterized by intraepithelial blister formation involving skin and mucous membranes where autoantibodies play a critical role in the pathogenesis of PV. The autoantibodies are directed against keratinocyte self adhesion antigens; Dsg1 (desmoglein1) and Dsg3 (desmoglein3). Thus, they inhibit the intercellular adhesion between keratiocytes resulting in suprabasalacantholysis pathologically that manifests clinically by the pemphigus vulgaris phenotype. Aim of work: To correlate the clinical disease severity and the pathogenicity of the autoantibodies of pemphigus vulgaris patients. Patients and method: Thirty egyptian PV patients recruited from Kasr Al- Aini outpatient clinic were examined for assessment of severity of the disease using pemphigus disease area index (PDAI) score. Blood samples were obtained from all the subjects, sera were extracted. One ml of sera was injected into prepared 4mm normal skin specimens that were incubated at 37o C for 48 hours, processed,stained byhematoxylin and eosin, and examined under light microscopy for assessment of the pathogenicity by organ culture acantholysis index (OCAI). The remaining sera were used for detection of anti-Dsg3 and anti-Dsg1 antibodies titres using ELISA. We also used EDTA treated ELISA to detect autoantibodies against non calcium dependent epitopes |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Autoantibodies |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Desmoglein |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Pemphigus Vulgaris |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Laila Ahmed Rashed , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Marwah Adly Mohamed Saleh , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Solwan Ibrahim Elsamanoudy , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Shimaa |
| Reviser | Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.11.10.M.Sc.2019.Ay.C | 01010110079851000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.11.10.M.Sc.2019.Ay.C | 01020110079851000 | 22.09.2023 | CD - Rom | 79851.CD |