Synthesis of some new azoles and their fused derivatives of expected biological activity / (Record no. 75197)
[ view plain ]
| 000 -LEADER | |
|---|---|
| fixed length control field | 02707cam a2200325 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223032438.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 191114s2019 ua d f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.12.10.Ph.D.2019.Mo.S |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Mona Said Mohammed Mahdy |
| 245 10 - TITLE STATEMENT | |
| Title | Synthesis of some new azoles and their fused derivatives of expected biological activity / |
| Statement of responsibility, etc. | Mona Said Mohammed Mahdy ; Supervised Eman Ali Ragab |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | تشييد بعض الآزولات و مشتقاتها الملتحمة الجديدة ذات نشاط بيولوجى متوقع |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Mona Said Mohammed Mahdy , |
| Date of publication, distribution, etc. | 2019 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 229 P. : |
| Other physical details | charts ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (Ph.D.) - Cairo University - Faculty of Science - Department of Organic Chemistry |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Pyrazoles 4a, b, 7a-d and 10 obtained by reaction of 5-amino-3-cyanomethyl- 1H-pyrazole-4-carbonitrile 1 with each of arylsulfonyl chlorides, chloroacetamide derivatives and ethyl chloroacetate, respectively. The condensation of pyrazoles 4a,b, 7a-d and 10 with various aromatic aldehydes afforded the corresponding arylidene 12a-c, 15a-r and 17a-c, respectively. The antimicrobial activity of some new selected products was also investigated. Compound 1 also reacted with each of acetoacetanilide and chalcone afforded pyrazolo[1,5-a]pyrimidine 30 and 42, respectively. Condensation of 30 and 42 with various aromatic aldehydes afforded the corresponding arylidene 31a-i and 44a-g, respectively. Coupling of compounds 30 and 42 with aryldiazonium chlorides led to formation of 2- arylhydrazono derivatives 40a-d and 47a-d, respectively. The anticancer activity of some new selected products was also investigated, enzyme inhibition, cell cycle and apoptosis. Cyclocondensation of benzoylglycine with aromatic aldehyde give new oxazolone derivative 54a,b and 56. Oxazolone 4a,b heated with different aromatic amines gave imidazole 60a-h, also, compounds 54a,b heated with bis-amines to afford bis-imidazole derivatives 66a,b and 68a,b. The in vivo anti-inflammatory activity studied for some synthesized imidazole, also enzyme inhibition against COX-2 and DHFR enzyme. In silico study for some synthesized compounds were carried out (Molecular docking and lipiniski's rule of five) |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | 5-amino-3-cyanomethyl-1H-pyrazole-4-carbonitrile |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Chalcone |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | The antimicrobial activity |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Eman Ali Ragab , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Samia |
| Reviser | Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.12.10.Ph.D.2019.Mo.S | 01010110079923000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.12.10.Ph.D.2019.Mo.S | 01020110079923000 | 22.09.2023 | CD - Rom | 79923.CD |