Radiotherapeutic impact on cancerous cell radiosensitivity of silica-coated iron oxide nanoparticles / (Record no. 76127)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 03047cam a2200349 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223032507.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 191228s2019 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | M.Sc |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.12.04.M.Sc.2019.Om.R |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Omnia Ashraf Saad Ali Elsawaby |
| 245 10 - TITLE STATEMENT | |
| Title | Radiotherapeutic impact on cancerous cell radiosensitivity of silica-coated iron oxide nanoparticles / |
| Statement of responsibility, etc. | Omnia Ashraf Saad Ali Elsawaby ; Supervised Wael M. Elshemey , Heba Mohamed Fahmy , Mohamed Mahmoud Fathy |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | التأثير العلاجى لجسيمات أكسيد الحديد النانوية المغلفة بالسيليكا علي الحساسية الإشعاعية للخلايا السرطانية |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Omnia Ashraf Saad Ali Elsawaby , |
| Date of publication, distribution, etc. | 2019 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 86 P. : |
| Other physical details | charts , facsimiles ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (M.Sc.) - Cairo University - Faculty of Science - Department of Biophysics |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Radiation therapy (RT) is one of the most commonly used non-surgical interventions in cancer therapy. Due to reported radioresistance of many cancer cells, radiosensitizers are introduced to cancer cells as a tool to overcome such radioresistivity. There have been several attempts to use high-atomic number nanoparticles as radiosensitizer agents in cells. In this study, a novel nanoradiosensitizer composed of magnetic nanoparticle core coated with silica was successfully prepared and applied to overcome cancer radioresistance. The prepared nanoparticles were characterized by transmission electron microscope (TEM), dynamic light scattering (DLS), atomic force microscopy (AFM) and vibration sample magnetometer (VSM). The radioenhancing effects of iron oxide magnetic nanoparticles (IO-MNPs) and silica-coated iron oxide magnetic nanoparticles (SIO-MNPs) were examined in breast cancer cells (MCF7) by MTT and comet assays. MCF7 cells were treated with different concentrations of the prepared nanoparticles and exposed to electron beam and X-ray photon beam at doses of 0, 0.5, 1, 2, 4 Gy. DLS diameters of IO-MNPs and SIO-MNPs were 18 ± 4.5 nm and 164 ± 16 nm, respectively. For electron beam, MCF7 cells treated with 5, 10, 20, 40 and 80 æg /ml of SIO-MNPs and exposed to 4 Gy showed dose enhancement factor (DEF) values of 1.03, 1.32, 1.29, 1.42 and 1.64 respectively. For X-ray beam, DEF values of cells treated with 20, 40 and 80 æg /ml of SIO-MNPs and exposed to 1 Gy were 1.43, 1.65 and 2.20 respectively |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Iron oxide magnetic nanoparticles (IO-MNPs) |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | MCF7 cell lines |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Silica-coated iron oxide magnetic nanoparticles (SIO-M NPs) |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Heba Mohamed Fahmy , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Mohamed Mahmoud Fathy , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Wael M. Elshemey , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Shimaa |
| Reviser | Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.12.04.M.Sc.2019.Om.R | 01010110080527000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.12.04.M.Sc.2019.Om.R | 01020110080527000 | 22.09.2023 | CD - Rom | 80527.CD |