Formulation and characterization of promising carrier systems for pulmonary drug delivery / (رقم التسجيلة. 76716)
[ عرض عادي ]
| 000 -LEADER | |
|---|---|
| fixed length control field | 02715cam a2200337 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223032525.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 200220s2020 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.08.08.Ph.D.2020.Om.F |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Omar Ali Abdalla Elkady |
| 245 10 - TITLE STATEMENT | |
| Title | Formulation and characterization of promising carrier systems for pulmonary drug delivery / |
| Statement of responsibility, etc. | Omar Ali Abdalla Elkady ; Supervised Hanan M. Ellaithy , Mina Ibrahim Tadros |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | صياغة وتوصيف أنظمة حمل واعدة لتوصيل العقار رئويا |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Omar Ali Abdalla Elkady , |
| Date of publication, distribution, etc. | 2020 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 131 P. : |
| Other physical details | charts , facsimiles ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Pharmaceutics |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Risedronate sodium (RS) is a potent inhibitor of bone resorption; having an extreme poor permeability and limited oral bioavailability (0.62%). RS should be orally administered under fasting conditions, while keeping in an upright posture for at least 30 min, to diminish common gastroesophageal injuries. To surmount such limitations, novel Risedronate-chitosan (RS-CS) crosslinker-free nebulizable microspheres were developed adopting quality by design (QbD) approach and Risk assessment (RA) thinking. RS:CS ratio, surfactant (Pluronic® F127) concentration, homogenization duration, speed and temperature were identified using Ishikawa diagrams as the highest formulation- and process-risk factors affecting the critical quality attributes (CQAs); average particle size (PS) and entrapment efficiency (EE%). The risk factors were screened using Plackett-Burman design and the levels of the most significant factors were optimized using a multi-level factorial-design to explore the optimized system with the least PS, maximum EE% and a prolonged drug release profile. The optimized system (B6) was developed at RS:CS ratio of 1:7, a surfactant concentration of 2% (w/v) and a homogenization speed of 14000 rpm. It revealed well correlation with QbD theoretical prediction where, positively charged (47.9±3.39 mV) discrete, spherical microspheres (3.47±0.16 æm), having a high EE% (94.58±0.19%) and prolonged RS release over 12 hours (Q12h, 89.70±0.64%) were achieved |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Chitosan |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Crosslinker-free |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Risedronate sodium |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Hanan M. Ellaithy , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Mina Ibrahim Tadros , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Asmaa |
| Reviser | Cataloger |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.08.08.Ph.D.2020.Om.F | 01010110080863000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.08.08.Ph.D.2020.Om.F | 01020110080863000 | 22.09.2023 | CD - Rom | 80863.CD |