New approaches for the synthesis of novel heterocyclic compounds derived from cyanomethylene and Ý-diketone compounds and determination of their biological effect / (Record no. 76814)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 02894cam a2200337 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223032529.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 200229s2020 ua d f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | M.Sc |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.12.10.M.Sc.2020.Ib.N |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Ibram Refat Boshra Mikhail |
| 245 10 - TITLE STATEMENT | |
| Title | New approaches for the synthesis of novel heterocyclic compounds derived from cyanomethylene and Ý-diketone compounds and determination of their biological effect / |
| Statement of responsibility, etc. | Ibram Refat Boshra Mikhail ; Supervied Rafat Milad Mohareb , Noha M. H. Elnagdi |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | إتجاهات جديدة لتحضير مركبات جديدة غير متجانسة الحلقة مشتقة من مركبات السيانوميثيلين والبيتا ثنائى الكيتون وتعيين تأثيرها البيولوجى |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Ibram Refat Boshra Mikhail , |
| Date of publication, distribution, etc. | 2020 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 169 P. : |
| Other physical details | charts ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (M.Sc.) - Cairo University - Faculty of Science - Department of Organic Chemistry |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Pyrazoles are an important heterocyclic family due to their wide spectrum of biological properties such as the anti-proliferative activities and inhibition toward tyrosine kinases. In the present work we started with pyrazole derivative (3) produced through the reaction of ethyl benzoylacetate (1) with hydrazine hydrate (2) followed by its heterocyclization to produce fused derivatives. The target compounds were synthesized in steps outlined in Schemes 1-6. The reaction of the pyrazole (3) with elemental sulfur and phenylisothiocyanate (4) gave the derivative (5). The molecular structure of compound (5) was confirmed on the basis of its elemental and spectral data. On the other hand, the reaction of compound (3) with ethyl orthoformate gave the 4-ethoxymethyleno derivative (6). The presence of the ketone and the active methylene moieties in compound (3) enhanced the synthesis of thieno[3,2-c]pyrazol derivatives using Gewald{u2019}s thiophene synthesis. Next, we moved towards the formation of some heterocyclic compounds starting from compound (3). The anti-proliferative activities of the newly synthesized compounds were evaluated against the six cancer cell lines. It is clear that compounds 8b, 9, 12b, 12d, 14b, 15b, 18d, 18f, 19b and 21d were the most active compounds. Several tests as Melting point, IR spectra, ¹H-NMR spectra, Mass spectra and analytical data (element analysis) have been made on all components |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Pyran |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Pyrazol derivatives |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Pyridine |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Noha M. H. Elnagdi , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Rafat Milad Mohareb , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Shimaa |
| Reviser | Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.12.10.M.Sc.2020.Ib.N | 01010110080903000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.12.10.M.Sc.2020.Ib.N | 01020110080903000 | 22.09.2023 | CD - Rom | 80903.CD |