Studying HCV IRES sequence and structure for genotype 4a-in correlation to interferon ribavirin responding treatment in Egyptian patients using bioinformatics / (رقم التسجيلة. 77636)
[ عرض عادي ]
| 000 -LEADER | |
|---|---|
| fixed length control field | 03083cam a2200349 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223032554.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 200908s2020 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | M.Sc |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.12.25.M.Sc.2020.Is.S |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Ismail Mohamed Rafeky Hussien Saad |
| 245 10 - TITLE STATEMENT | |
| Title | Studying HCV IRES sequence and structure for genotype 4a-in correlation to interferon ribavirin responding treatment in Egyptian patients using bioinformatics / |
| Statement of responsibility, etc. | Ismail Mohamed Rafeky Hussien Saad ; Supertvised Fawzy Ali Ataby , Salwa Farouk Sabet , Mohamed Ali Saber |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | دراسة المنطقه المسؤله عن الدخول الي الريبوسوم الداخلى فى فيروس التهاب الكبدى سى من حيث التسلسل النيكولتيدى و التركيب الثانوى للسلاله ( 4أ) و علاقه ذلك بالاستجابه لعلاج الانترفيرون\ريبافيرين فى حالات المرضى المصرين باستخدام المعلوماتية الحيوية |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Ismail Mohamed Rafeky Hussien Saad , |
| Date of publication, distribution, etc. | 2020 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 113 P. : |
| Other physical details | charts , facsimiles ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (M.Sc.) - Cairo University - Faculty of Science - Department of Biotechnology |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Hepatitis C virus infection is the major cause of chronic hepatitis. The HCV genotype 4a is predominant in Egyptian patients that are not responding to the combined pegylated interferon-alpha /ribavirin therapy. The HCV IRES is a well-defined structure of about 341 nucleotides in its 5{u00B4}-untranslated region (UTR). This study was conducted on 46 Quantification of HCV-RNA in serum has been carried out at the beginning of treatment (W0) and at week12 (W12), patients 26 responders and 20 non-responders to Study HCV IRES Sequence and Secondary Structure and find the Correlation to pegylated Interferon\Ribavirin Responding Treatment in Egyptian patients. There was no statistically significant difference between Responders and Non-Responders regarding gender (P=0.1), age (p=0.3), AFP (p=0.4) and Albumin (p=0.1) while There was a significant increase for AST/ALT (p=0.002, p=0.001) respectively. HCV IRES RT-PCR and sequence analysis including genotyping, MSA and Sequence variation showed that 98% genotype 4a and there was no significant difference in sequence between Responders and Non-Responders patients in addition to the prediction of HCV IRES secondary structure MFE,Centroid revealed that there was no effect on IRES secondary structure and it is conserved among all HCV genotypes |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Genotype 4a |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Hepatitis C Virus (HCV) |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Polymerase Chain Reaction (qPCR) |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Fawzy Ali Ataby , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Mohamed Ali Saber , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Salwa Farouk Sabet , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Shimaa |
| Reviser | Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.12.25.M.Sc.2020.Is.S | 01010110081454000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.12.25.M.Sc.2020.Is.S | 01020110081454000 | 22.09.2023 | CD - Rom | 81454.CD |