Synthesis of some fused heterocycles from laboratory available starting materials / (رقم التسجيلة. 78084)
[ عرض عادي ]
| 000 -LEADER | |
|---|---|
| fixed length control field | 03146cam a2200337 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223032609.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 201005s2020 ua f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.12.10.Ph.D.2020.Mo.S |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Mohamed Sayed Mohamed Mohamed Farghaly |
| 245 10 - TITLE STATEMENT | |
| Title | Synthesis of some fused heterocycles from laboratory available starting materials / |
| Statement of responsibility, etc. | Mohamed Sayed Mohamed Mohamed Farghaly ; Supervised Fathy Mohamed Abdelrazek , Sobhy Mohamed Gomaa |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | تحضير بعض الحلقيات غير متجانسة الملتحمة من بادئات متوافرة معمليا |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Mohamed Sayed Mohamed Mohamed Farghaly , |
| Date of publication, distribution, etc. | 2020 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 197 P. ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (Ph.D.) - Cairo University - Faculty of Science - Department of Organic Chemistry |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | A novel series of 1,5-dihydropyrido-triazolo-pyrimidine derivatives were prepared by cyclocondensation of 2-thioxo-pyrido[2,3-d]pyrimidines (prepared from reaction of chalcone with 6-aminothiouracil) with a variety of hydrazonoyl chlorides. 3-Methyl-5-oxo-4-(2-arylhydrazono)-4,5-dihydro-1H-pyrazole-1-carbothioamides (obtained from the reaction of ethyl 3-oxo-2-(2-arylhydrazono)butanoates with thiosemicarbazide) could be transformed into a variety of thiazolyl-pyrazole derivatives via their reaction with a diversity hydrazonoyl chlorides as well as bromoacetyl derivatives. Grinding a mixture of 6-aminopyrimidine-2,4-(1H, 3H)dione, 6-amino-2-thioxo-2,3- dihydropyrimidine-4(1H)-one or ethyl 7-amino-5-oxo-1-aryl-1,5-dihydro[1,2,4]-triazolo[4,3- a]pyrimidine-3-carboxylate derivatives with 1,2-diphenylethanone and different aromatic aldehydes in presence of aluminate sulfonic acid nanoparticles (ASA NPs) in a one pot solvent-free conditions, afforded the pyrido[2,3-d]pyrimidinone derivatives and ethyl 5-oxo- 1-aryl-6,7,8-triphenyl-1,5,6,9-tetrahydropyrido[2,3-d][1,2,4]triazolo[4,3-a]pyrimidine-3- carboxylate derivatives respectively. All structures were elucidated by spectral and elemental analyses. Some structures were further proved by alternative synthesis. Some of the synthesized compounds are forced for molecular docking by using MOE 2014.010 Package software; one of in-silico study tools. These compounds are targeting Human Cyclin Defendant Kinase 2 (CK2) PDB ID (1PXO.Protein data bank) due to its important role in controlling of the human cell cycle and also for meiosis. Moreover, the computational studies were carried out for some new compounds.The results indicated that these compounds showed promising binding affinities against the active site of the epidermal growth factor receptor kinase (EGFR) |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Cyclocondensation |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Hydrazonoyl halides |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Pyrido[2,3-d]pyrimidine |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Fathy Mohamed Abdelrazek , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Sobhy Mohamed Gomaa , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Shimaa |
| Reviser | Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.12.10.Ph.D.2020.Mo.S | 01010110081635000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.12.10.Ph.D.2020.Mo.S | 01020110081635000 | 22.09.2023 | CD - Rom | 81635.CD |