Assessment of the expression of IL-27 in patients with psoriasis vulgaris / (Record no. 78279)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 02945cam a2200349 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223032615.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 201018s2020 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | M.Sc |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.11.10.M.Sc.2020.He.A |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Heba Ahmed Abdelgayed Ibrahim |
| 245 10 - TITLE STATEMENT | |
| Title | Assessment of the expression of IL-27 in patients with psoriasis vulgaris / |
| Statement of responsibility, etc. | Heba Ahmed Abdelgayed Ibrahim ; Supervised Mohammed Hussein Medhat Elkomy , Olfat Gamil Shaker , Aya Magdi Ibrahim Alorbani |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | قياس مستوى مادة انترليوكين 27 فى مرضى الصدفية |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Heba Ahmed Abdelgayed Ibrahim , |
| Date of publication, distribution, etc. | 2020 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 117 P. : |
| Other physical details | charts , facsimiles ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Dermatology and Venerology |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Background: Although it is now considered a prototypic Th1/Th17-mediated disease, several gaps still exist in our understanding of the pathogenesis of psoriasis. IL-27 is a novel cytokine of the IL-12 family. Research on IL-27 uncovered its pleiotropic rolein the differentiation and function of distinct T-cell subsets. Previous studies have proposed that IL-27 may be involved in the complex pathogenesis of psoriasis. Objective: Our aim is tostudy the expression of IL-27 inpatients with psoriasis in comparison to controls, and to assess its relation to clinical disease parameters. Methods: 25 psoriatic patients and 30 age, sex and skin type matched controls were included. Full clinical examination was done and both tissue and serum levels of IL-27 were measured by ELISA. Results:The mean IL-27 levels in both tissue and serum of psoriasis patients were significantly higher when compared to controls (P=<0.001, 0.005 respectively). We also detected a significant negative correlation between the patients{u2019} sera levels of IL-27 and disease severity, expressed in both PASI score and extent of the disease, (P=0.007, 0.002, r=-0.528, -0.600 respectively). Limitations: Small sample size Conclusion: Based on the findings of our study, it can be speculated that IL-27 can serve as a protective cytokine that is upregulated as a counter measure at the early stages of psoriasis initiation, but with increasing disease activity, this cytokine is suppressed; by a yet to be elucidated mechanism, giving way for pro-inflammatory responses to overwhelm and exacerbate the condition |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Aetiopathogenesis-IL-27 |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Psoriasis |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Th1/17 |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Aya Magdi Ibrahim Alorbani , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Mohammed Hussein Medhat Elkomy , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Olfat Gamil Shaker , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Shimaa |
| Reviser | Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.11.10.M.Sc.2020.He.A | 01010110081757000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.11.10.M.Sc.2020.He.A | 01020110081757000 | 22.09.2023 | CD - Rom | 81757.CD |