Regulation of doxorubicin chemotherapeutic potential by MiR-520c-3p in hepatocellular carcinoma cells / (Record no. 78767)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 02691cam a2200349 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223032629.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 201115s2020 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.12.02.Ph.D.2020.Mo.R |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Mohamed Attia Ragheb Erfan |
| 245 10 - TITLE STATEMENT | |
| Title | Regulation of doxorubicin chemotherapeutic potential by MiR-520c-3p in hepatocellular carcinoma cells / |
| Statement of responsibility, etc. | Mohamed Attia Ragheb Erfan ; Supervised Mervat Elsayed Mohamed , Emad Mahmoud Ibrahim Elzayat , Abdelhady Ali Abdelwahab |
| 246 1# - VARYING FORM OF TITLE | |
| Title proper/short title | فى خلايا سرطان الكبد (MiR-520c-3p)تنظيم الامكانية العلاجية للدكسوروبيسين عن طريق الحمض الميكروريبوزى النووى |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Mohamed Attia Ragheb Erfan , |
| Date of publication, distribution, etc. | 2020 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 160 P . : |
| Other physical details | charts , facsmilies ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (Ph.D.) - Cairo University - Faculty of Science - Department of Biochemistry |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Background: Doxorubicin (Dox) is one of the most common drugs used in cancer therapy, including hepatocellular carcinoma (HCC). Drug resistance, is one of chemotherapy{u2019}s significant problems. Emerging studies have shown that microRNAs (miRNAs) could participate in regulating this mechanism. Nevertheless, the impact of miRNAs on HCC chemoresistance is still enigmatic. Objective: Investigating the role of a candidate miRNA in enhancement of anti-tumor effects of Dox against HepG2 cells. Expression profile for liver related miRNAs (384 miRNAs) has been analyzed on HepG2 cells treated with Dox using qRT-PCR. miR- 520c-3p, the most deregulated miRNA, was selected for combination treatment with Dox. Methods: Expression level for LEF1, CDK2, CDH1, VIM, Mcl-1 and p53 was evaluated in miR-520c-3p transfected cells. Cell viability, colony formation, wound healing as well as apoptosis assays have been demonstrated. Furthermore, Mcl-1 protein level was measured using a western blot technique. Results: The present data indicates that miR-520c-3p overexpression could render HepG2 cells chemo-sensitive to Dox through enhancing its suppressive effects on proliferation, migration, and induction of apoptosis |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Chemosensitivity |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Hepatocellular carcinoma |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | miR-520c-3p |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Abdelhady Ali Abdelwahab , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Emad Mahmoud Ibrahim Elzayat , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Mervat Elsayed Mohamed , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Amira |
| Reviser | Cataloger |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.12.02.Ph.D.2020.Mo.R | 01010110082029000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.12.02.Ph.D.2020.Mo.R | 01020110082029000 | 22.09.2023 | CD - Rom | 82029.CD |