Role of osteoprotegerin (OPG) level and its gene polymorphism in the pathogenesis of osteoporosis in thalassemia major / (Record no. 78862)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 03104cam a2200349 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223032632.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 201121s2019 ua d f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | M.Sc |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.11.28.M.Sc.2019.Mo.R |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Mohamed Madboly Mohamed Soliman |
| 245 10 - TITLE STATEMENT | |
| Title | Role of osteoprotegerin (OPG) level and its gene polymorphism in the pathogenesis of osteoporosis in thalassemia major / |
| Statement of responsibility, etc. | Mohamed Madboly Mohamed Soliman ; Supervised Ilham Youssry Ibrahim , Rania Mohamed Samy , Dalia Salah Eldin Ahmed |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | دور مستوى الاستيوبروتيجرين فى الدم وتعدد جيناته فى الألية المرضية لمرض هشاشة العظام فى أنيميا البحر المتوسط |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Mohamed Madboly Mohamed Soliman , |
| Date of publication, distribution, etc. | 2019 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 172 P. : |
| Other physical details | charts , facimiles ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Pediatrics |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Background: Osteoporosis is a prominent cause of morbidity in patients with thalassemia major (TM) with a complex pathophysiology. Osteoprotegerin (OPG) and receptor activator of NF-kappa-B ligand (RANKL) have been recently implicated in the pathogenesis of various types of osteoporosis. Aims: To characterize the possible role of the OPG and its gene polymorphisms in the pathogenesis of osteoporosis in thalassemia major, as well as their relationship with bone mineral density (BMD). Patients and methods: In 60 Egyptian thalassemic patients and 60 healthy control children (age = 5-14 year), serum OPG measured by ELIZA and OPG single nucleotide polymorphisms (SNPs) (rs2073618 and rs2073617) detected by PCR-RFLP technique.The patients had recent results of BMD scanning using dual X-ray absorptiometry (DEXA). Results: High prevalence of bone diseases was detected in TM patients, 40% had spine low bone mass, 10% had femur low bone mass, 70% complained from bone pain, 8.3% had history of long bone fracture related to minor trauma, and one patient had osteoporosis.The thalassemic patients showed significantly lower serum levels of OPG (P=0.003) and OPG/RANKL ratio (P= < 0.0001) as compared with controls. We couldn{u2019}t demonstrate significant association between serum OPG levels and BMD. Concerning OPG SNP rs2073618 we found that the G allele (P = 0.006) and GC genotype (p = 0.001) occurred more frequently in thalassemic patients with femur low bone mass than those with femur BMD Z- score > -2. While there was no relation between OPG SNP rs2073617 and BMD at any site of measurements |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Osteoporosis |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Osteoprotegerin (OPG) |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Thalassemia major (TM) |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Dalia Salah Eldin Ahmed , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Ilham Youssry Ibrahim , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Rania Mohamed Samy , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Shimaa |
| Reviser | Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.11.28.M.Sc.2019.Mo.R | 01010110082079000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.11.28.M.Sc.2019.Mo.R | 01020110082079000 | 22.09.2023 | CD - Rom | 82079.CD |