Assessment of genetic mutations associated with colorectal cancer in Egyptian patients using next generation sequencing / (Record no. 79094)
[ view plain ]
| 000 -LEADER | |
|---|---|
| fixed length control field | 03415cam a2200349 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223032640.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 201205s2020 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | M.Sc |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.12.21.M.Sc.2020.No.A |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Nourhan Hussien Mekky Mohamed |
| 245 10 - TITLE STATEMENT | |
| Title | Assessment of genetic mutations associated with colorectal cancer in Egyptian patients using next generation sequencing / |
| Statement of responsibility, etc. | Nourhan Hussien Mekky Mohamed ; Supervised Salwa Farouk Sabet , Heba Bassiony Atwa , Wafaa Hassan Elmetnawy |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | تقييم الطفرات الجينية المصاحبة لسرطان القولون /المستقيم فى المرضى المصريين باستخدام تقنية الجيل التالى للتسلسل الجينى |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Nourhan Hussien Mekky Mohamed , |
| Date of publication, distribution, etc. | 2020 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 127 P. : |
| Other physical details | charts , facsimiles ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (M.Sc.) - Cairo University - Faculty of Science - Department of Zoology |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Colorectal cancer (CRC) is a disease originating from the epithelial cells lining the colon or rectum of the gastrointestinal tract. In most CRC cases, the DNA mutations that lead to cancer are acquired during a person's life rather than having been inherited.There are certain risk factors that probably play a role in causing these acquired mutations, but so far most of them are not known. The functions of the major colon cancer genes have been reasonably well characterized. The most commonly mutated gene in all CRC is the Adenomatous Polyposis Coli (APC) gene, which produces the APC protein; it stops the accumulation of Ý-catenin protein. The p53 protein, produced by the TP53 gene, it normally controls a check point in cell division. TP53 gene mutations can transform an adenoma into an invasive carcinoma. Some genes in CRC that encoding the proteins KRAS, NRAS, B-RAF, and PI3K, can acquire mutations that result in over-activation of cell proliferation which constitutively stimulate the cell to divide. PTEN, a tumor suppressor gene, it normally inhibits PI3K, but can sometimes become mutated and deactivated. c-MET gene when overexpressed it is associated with greater tumor size in primary CRC, and also it is an important predictive marker for early-stage invasion and metastasis. Most pathogenic mutations in this major genes lead to a higher risk of disease, and environmental contributions are often difficult to recognize. We investigated these major genes and their correlation using the advanced technique Next generation sequencing (NGS). This is the first study to report hotspot mutations, genes overlapping and mutations co-occurrence in potential biomarkers using NGS in CRC patients in Egypt.Thus, this study can provide insights for developing targeted therapies with enhanced effect and help in optimizing personalized cancer therapy |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Colorectal Cancer (CRC) |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Kirsten rat sarcoma viral oncogene homolog (KRAS) |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Next generation sequencing (NGS) |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Heba Bassiony Atwa , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Salwa Farouk Sabet , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Wafaa Hassan Elmetnawy , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Shimaa |
| Reviser | Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.12.21.M.Sc.2020.No.A | 01010110082253000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.12.21.M.Sc.2020.No.A | 01020110082253000 | 22.09.2023 | CD - Rom | 82253.CD |