Radio sensitization effect of 5-fluorouracil modified with zinc oxide nanoparticles on human cell lines / (رقم التسجيلة. 79166)
[ عرض عادي ]
| 000 -LEADER | |
|---|---|
| fixed length control field | 02762cam a2200349 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223032642.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 201210s2020 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | M.Sc |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.12.25.M.Sc.2020.No.R |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Noha Ashraf Hassan |
| 245 10 - TITLE STATEMENT | |
| Title | Radio sensitization effect of 5-fluorouracil modified with zinc oxide nanoparticles on human cell lines / |
| Statement of responsibility, etc. | Noha Ashraf Hassan ; Supervised Mohamed Aly Edesouky , Abdellatif Mohamed Salah Eldin , Soheir Saad Korraa |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | تأثير الحساسية الأشعاعية لل 5- فلورويوراسيل المعدل بالجسيمات النانونية لأكسيد الزنك على خطوط الخلايا البشرية |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Noha Ashraf Hassan , |
| Date of publication, distribution, etc. | 2020 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 164 P. : |
| Other physical details | charts , facsmilies ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (M.Sc.)- Cairo University - Faculty of Science - Department of Biotechnology |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | The aim of the study is to load 5-fluorouracil on zinc oxide nanoparticles that modified with cetrimonium bromide (CTAB) to synthesize the nanocomposite for enhancing the anticancer activity of 5-FU. The in vitro anticancer activity of this nanocomposite was evaluated without and with radiation on three different cancer cell lines (HepG2, HUH- 7 and MCF-7) and one normal cell line (WI-38) by MTT assay after 24 and 48 hr in comparison to 5-FU and nanocomposite without radiation respectively. The expression of apoptotic genes (P 53 and Bax) and antiapoptotic gene (Bcl-2) was investigated by using liver cancer cell line (HepG2) and also the level of lipid peroxidation and antioxident molecules and enzymes was measured by using different treatments whether combined or not with radiation. The results showed that the nanocomposite exerted better anticancer activity against different cancer cells while posing minimal effect on normal cell line after 24 and 48hr in comparison with pure 5-FU. Then nanocomposite with radiation exerted better anticancer activity than pure nanocomposite after 48 hr on HepG2. Nanocomposite not only potentiated the toxic effects of radiation and led to a higher rate of cell death but also, enhanced the increase in apoptotic genes expression and decrease in antiapoptotic genes expression |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | 5-Fluorouracil |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | CTAB |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Zinc oxide NPs |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Abdellatif Mohamed Salah Eldin , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Mohamed Aly Edesouky , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Soheir Saad Korraa , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Amira |
| Reviser | Cataloger |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.12.25.M.Sc.2020.No.R | 01010110082294000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.12.25.M.Sc.2020.No.R | 01020110082294000 | 22.09.2023 | CD - Rom | 82294.CD |