Synthesis of some new heterocyclic compounds from nitrile derivatives / (Record no. 79264)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 02515cam a2200325 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223032645.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 201219s2020 ua f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.12.10.Ph.D.2020.Ma.S |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Marwa Maher Abdelmohsen Bayoumi |
| 245 10 - TITLE STATEMENT | |
| Title | Synthesis of some new heterocyclic compounds from nitrile derivatives / |
| Statement of responsibility, etc. | Marwa Maher Abdel Mohsen Bayoumi ; Supervised Sanaa Osman Abdallah |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | تشييد بعض المركبات غير المتجانسة الحلقة الجديدة من مشتقات النيترين |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Marwa Maher Abdel Mohsen Bayoumi , |
| Date of publication, distribution, etc. | 2020 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 222 P. ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (Ph.D.) - Cairo University - Faculty of Science - Department of Organic Chemistry |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | The starting N,N-bis(cyanoacetyl)hydrazine 3 was prepared by the reaction of cyanoacetic acid hydrazide 1 and 3-(3 ,5-dimethyl-1H-pyrazol-1-yl)-3- oxopropanenitrile 2. Condensation of compound 3 with each of aromatic aldehydes 4a-k, o-hydroxybenzaldehydes 8a,b and azosalicylaldehydes 12a-e under grind stone method afforded the respective arylmethylene derivatives Sak, his-coumarin derivatives lla,b and 15a-e, respectively. Coupling of 3 with aryldiazonium chlorides gave arylhydrazono derivatives 17a-e. Also , antimicrobial activity for some new products, enzyme inhibition and agarose gel electrophoresis were investigated. Next, malononitrile considered as the starting material to prepare 5-amino-3- (cyanomethyl)-1-phenyl-lH-pyrazole-4-carbonitrile 20. Acid hydrolysis of compound 20 gave 3-amino-2-phenyl-2,7-dihydro-4H-pyrazolo[ 4,3-c ]pyridine- 4,6(5H)-dione 39. Condensation of each of 20 and 39 with various aromatic aldehydes afforded the corresponding arylmethylenes 23a-i and 40a-I, respectively. Coupling of 39 with aryldiazonium chlorides led to formation of arylhydrazono derivatives 53a-e.Moroever, acetylation of 39 yielded the Nacetyl derivative 43. The anticancer activity of some of the newly synthesized compounds was investigated. Also, molecular docking study was performed |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Antimicrobial activity |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Bis-coumarins |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | N,N-bis( cyanoacetyl)hydrazine |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Sanaa Osman Abdallah , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Shimaa |
| Reviser | Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.12.10.Ph.D.2020.Ma.S | 01010110082337000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.12.10.Ph.D.2020.Ma.S | 01020110082337000 | 22.09.2023 | CD - Rom | 82337.CD |