Mutation patterns of Epidermal Growth Factor Receptor (EGFR) gene in Non-Small Cell Lung Cancer (NSCLC) of Egyptian patients / (Record no. 79465)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 03220cam a2200349 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223032651.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 210104s2020 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | M.Sc |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.12.21.M.Sc.2020.Mo.M |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Mona Mahmoud Qenawi Farrag |
| 245 10 - TITLE STATEMENT | |
| Title | Mutation patterns of Epidermal Growth Factor Receptor (EGFR) gene in Non-Small Cell Lung Cancer (NSCLC) of Egyptian patients / |
| Statement of responsibility, etc. | Mona Mahmoud Qenawi Farrag ; Supervised Salwa Farouk Sabet , Heba Bassiony Atwa , Wafaa Hassan Elmetnawy |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | أنماط الطفرات لجين مستقبلات عامل نمو البشرة فى سرطان الرئة ذى الخلايا غير الصغيرة للمرضى المصريين |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Mona Mahmoud Qenawi Farrag , |
| Date of publication, distribution, etc. | 2020 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 101 P. : |
| Other physical details | charts , facimiles ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (M.Sc.) - Cairo University - Faculty of Science - Department of Zoology |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Background: Mutations of epidermal growth factor receptor (EGFR) gene have been reported to be linked with non{u2013}small cell lung cancer (NSCLC) and associated with the responsiveness of tumors to EGFR tyrosine kinase inhibitors. This study aimed to assess the frequency of EGFR mutations in Egyptian patients with NSCLC adenocarcinoma. Patients and Methods: Formalin-fixed paraffinembedded (FFPE) tissue blocks were prepared from 120 NSCLC patients and 20 healthy volunteers. DNA extracted from FFPE samples was used for PCR amplification using biotinylated primers. The amplified products were hybridized to a test strip containing allele-specific oligonucleotide probes immobilized as an array of parallel lines using the Vienna Lab Strip Assays kit and EGFR mutations were identified. Results: EGFR mutations were detected in forty nine (40.8%) patients, whereas 71 (59.1%) patients were non-mutant. Moreover, the most common mutations were found in exon 19 (55.1% of the all mutations) and exon 21 (26.5% of the all mutations), whereas the mutations in the other exons were less common; mutations in exons 18 and 20 represented only 10.2 % and 8.2% respectively. We found that exon 21 mutation L858R (Leu858Arg) represents 22.4% of mutations and L747-P753 mutation in Ex19Del represents 18.4% of mutations which are the most common. On the other hand, no EGFR mutations were detected in the healthy individuals. Conclusion: EGFR mutations were determined in exons 18 to 21, where exons 19 and 21 were the most frequent mutations and were related to non-smokers and women. We recommend that somatic EGFR mutations are valuable biomarkers for NSCLC diagnosis and can be used for developing targeted therapy in the Egyptian population |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Epidermal Growth Factor Receptor (EGFR) |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Mutations |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Non{u2013}Small Cell Lung Cancer |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Heba Bassiony Atwa , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Salwa Farouk Sabet , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Wafaa Hassan Elmetnawy , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Shimaa |
| Reviser | Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.12.21.M.Sc.2020.Mo.M | 01010110082510000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.12.21.M.Sc.2020.Mo.M | 01020110082510000 | 22.09.2023 | CD - Rom | 82510.CD |