Effect of streptozotocin-induced diabetes mellitus on the cerebellar cortex of adult male albino rat and the curative role of stem cells versus curcumin : (Record no. 79776)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 03637cam a2200349 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223032701.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 210131s2020 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.11.02.Ph.D.2020.As.E |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Asmaa Kamel Hammad |
| 245 10 - TITLE STATEMENT | |
| Title | Effect of streptozotocin-induced diabetes mellitus on the cerebellar cortex of adult male albino rat and the curative role of stem cells versus curcumin : |
| Remainder of title | Histological, biochemical, immunohistochemical and gene expression Study / |
| Statement of responsibility, etc. | Asmaa Kamel Hammad ; Supervised Hafiz Waly Ahmed , Ayman Aboelenein Rizk , Shereen Abdelfattah Mohamed |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | تأثير مرض السكرى المستحث بالاستربتوزوتوسين على قشرة المخيخ فى ذكور الجرذان البيضاء البالغة والتأثير العلاجى للخلايا الجذعية مقارنة بالكركم : |
| Remainder of title | دراسة نسيجية كيميائية حيوية: هستوكيميائية مناعية و جينية |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Asmaa Kamel Hammad , |
| Date of publication, distribution, etc. | 2020 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 125 P. : |
| Other physical details | charts , facsimiles ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Anatomy |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Background: Diabetes mellitus is the disease, termed either by insulin paucity or resistance and hyperglycemia. The selection of the cerebellum was built on its specific functions.The aim of this study was to investigate a comparison between the possible therapeutic effects of MSCs and curcumin against fluctuations in the cerebellar cortex of STZ-induced diabetic albino rats. Materials and methods: Forty rats were divided into five groups: control, sham control, streptozotocin-induced diabetes, diabetes and MSCs administered and diabetes and curcumin administered. Light microscopic (H&E), immune-histochemical; Glial fibrillary acidic protein (GFAP) and caspase-3, real-time PCR; phospholipase-C (PLC) and Ü-synuclein, histomorphometric analysis, oxidative / anti-oxidatants; malondialdehyde (MDA)/ superoxide dismutase (SOD) glutathione (GSH) and were made. Results: The histopathological examination of the STZ-induced diabetic rats revealed alterations in the molecular, purkinje and granular layers. Abnormal organizations, vacuolation, patchy loss of purkinje cells were detected. Some purkinje cells migrated into the granular layer.Hemorrhage in pia mater outspreading to cerebellar layers is discerned. Purkinje cells showed karyorrhexis.The mean value of area percentage for GFAP and caspase-3 immune- reactivity revealed significant increase compared to that of the control group. Also, MDA level was significantly increased while the SOD and GSH levels were significantly lower when compared to the control group. Meanwhile, mean values of PLC demonstrated significant decrease, while Ü-synuclein levels displayed a significant increment in the diabetic group. Administration of curcumin and MSCs extremely ameliorated the previous alterations.Conclusion: the deleterious alterations on the cerebellar cortex induced by diabetes were obviously improved when treated with either MSCs or curcum |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Cerebellum |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Diabetes mellitus |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Stem cells |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Ayman Aboelenein Rizk , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Hafiz Waly Ahmed , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Shereen Abdelfattah Mohamed , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Shimaa |
| Reviser | Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.11.02.Ph.D.2020.As.E | 01010110082682000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.11.02.Ph.D.2020.As.E | 01020110082682000 | 22.09.2023 | CD - Rom | 82682.CD |