Anti-neoplastic activity of holothuria arenicola saponin against erlich ascites carcinoma in swiss albino mice / (Record no. 80379)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 03309cam a2200337 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223032720.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 210327s2020 ua d f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | M.Sc |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.12.21.M.Sc.2020.Sh.A |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Shimaa Anter Mahmoud |
| 245 10 - TITLE STATEMENT | |
| Title | Anti-neoplastic activity of holothuria arenicola saponin against erlich ascites carcinoma in swiss albino mice / |
| Statement of responsibility, etc. | Shimaa Anter Mahmoud ; Supervised Amel Mahmoud Soliman , Ayman Saber Mohamed |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | النشاط المضاد للأورام لصابونين الهولوثوريا أينيكولا ضد سرطان إيرلش الإستسقائى فى الفئران البيضاء السويسرية |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Shimaa Anter Mahmoud , |
| Date of publication, distribution, etc. | 2020 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 118 P. : |
| Other physical details | charts ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (M.Sc.) - Cairo University - Faculty of Science - Department of Zoology |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Cancer is a complex disease including various changes in cell physiology, which may lead to malignant tumors. The Ehrlich tumor is a quickly developing carcinoma with aggressive behavior. Saponins are important bioactive compounds in sea cucumbers that have an antioxidant, anti-microbial, anti-inflammatory, antiproliferative, and anti-tumor effect. The present investigation attempted to study the potential use of the Holothuria arenicola saponin (HaS) against Ehrlich Ascites Carcinoma (EAC) tumor model in female Swiss albino mice. Forty female Swiss albino mice were divided into four main groups (10 mice/group). Control, EAC, 5-fluorouracil (5-FU) and HaS treated groups. Control group daily injected intraperitoneally with 0.2 ml physiological saline from 0th day till the end of the experiment (10th day). Rest groups were inoculated with EAC cells (5 {u00D7} 10⁶ cells/mouse i.p.) at 0th day. Mice injected intraperitoneally with, 0.2 ml physiological saline (EAC), 5-FU (20 mg/kg) (5- FU) and saponin (120 mg/kg) (HaS) for 9 consecutive days. The HPLC studies of the extracted saponin showed the peak at retention time 5.19 min. was matched with the standard saponin with a total amount of 34.87%. HaS group showed a reduction in the Erlich ascetic volume (EAV), tumor cell count, the viability of tumor cells, and the activities of arginase, aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP) and creatinine, urea, uric, white blood cells (WBCs) and malondialdehyde (MDA).While it caused a general increase in the levels of hemoglobin (Hb), red blood cells (RBCs), platelets (Plt) and the activities of glutathione-S-transferase (GST), catalase (CAT) and glutathione reduced (GSH).The histopathological investigation showed clear improvement in the hepatic and kidney architecture. The results of this study clearly investigated that HaS is a potent natural product that has promising antineoplastic efficacy |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Holothuria arenicola |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Saponin |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Sea cucumber |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Amel Mahmoud Soliman , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Ayman Saber Mohamed , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Shimaa |
| Reviser | Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.12.21.M.Sc.2020.Sh.A | 01010110083028000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.12.21.M.Sc.2020.Sh.A | 01020110083028000 | 22.09.2023 | CD - Rom | 83028.CD |