Analytical study of some drugs treating benign prostatic hyperplasia / (رقم التسجيلة. 80387)
[ عرض عادي ]
| 000 -LEADER | |
|---|---|
| fixed length control field | 03578cam a2200349 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223032720.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 210327s2021 ua d f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | M.Sc |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.08.03.M.Sc.2021.Mi.A |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Mina Wadie Ibrahim |
| 245 10 - TITLE STATEMENT | |
| Title | Analytical study of some drugs treating benign prostatic hyperplasia / |
| Statement of responsibility, etc. | Mina Wadie Ibrahim ; Supervised Ezzat Mohamed Abdelmoety , Soheir Abdelfattah Ahmed Omar , Mamdouh Reda Rezk |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | دراسة تحليلية لبعض الأدوية المعالجة لتضخم البروستاتا الحميد |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Mina Wadie Ibrahim , |
| Date of publication, distribution, etc. | 2021 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 421 P. : |
| Other physical details | charts ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Analytical Chemistry |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | This thesis is concerned with the quantitative determination of some drugs used for treatment of benign prostatic hyperplasia and other coincident diseases. In this thesis, two binary mixtures were studied, separately, in their new pharmaceutical formulations. The first mixture contains Tamsulosin Hydrochloride (TAM) and Tadalafil (TAD), while the second one contains Alfuzosin Hydrochloride (ALF) and Solifenacin Succinate (SOL).The aim of this work was to develop different analytical methods that are characterized by simplicity, accuracy and appropriate degree of sensitivity for the analysis of the above-mentioned drugs in their pure forms, in their pharmaceutical formulations and in the presence of their degradation products and/or potential impurities. Smart UV-spectrophotometric, high-performance thin layer chromatographic (HPTLC) and high-performance liquid chromatographic (HPLC) methods were developed for the analysis of the first mixture (TAM and TAD). Moreover, the principles of green chemistry and Quality-by-Design approach were successfully implemented throughout the chromatographic separation.The greenness profile was assessed via several green metrics as GlaxoSmithKline solvent sustainability guide, environmental, health and safety (EHS) tool, national environmental methods index (NEMI) and Eco-Scale. Additionally, the stability of the two cited drugs was investigated under different stress conditions in accordance with ICH guidelines followed by developing stability-indicating high-performance thin layer chromatographic and high-performance liquid chromatographic methods.The second mixture (ALF and SOL) was assayed by eco-friendly UV-spectrophotometric and Quality-by-Design based HPLC methods in their binary mixtures. In addition, the two enantiomers of ALF were successfully separated along with SOL using 50-mm chiral column and ethanol as green organic solvent.The method was statistically optimized through experimental design. Moreover, stability-indicating high-performance thin layer chromatographic and high-performance liquid chromatographic methods were developed for the simultaneous determination of Alf and SOL along with their official impurities induced via stress stability studies |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Alfuzosin hydrochloride |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Chromatography |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Experimental design |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Ezzat Mohamed Abdelmoety , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Mamdouh Reda Rezk , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Soheir Abdelfattah Ahmed Omar , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Shimaa |
| Reviser | Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.08.03.M.Sc.2021.Mi.A | 01010110083033000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.08.03.M.Sc.2021.Mi.A | 01020110083033000 | 22.09.2023 | CD - Rom | 83033.CD |