MPL W515L/K mutations in myeloproliferative neoplasms / (Record no. 80429)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 03066cam a2200349 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223032721.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 210328s2021 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | M.Sc |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.12.25.M.Sc.2021.So.M |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Sohaila Ahmed Bahaa Eldein Mohamed Eldeweny |
| 245 10 - TITLE STATEMENT | |
| Title | MPL W515L/K mutations in myeloproliferative neoplasms / |
| Statement of responsibility, etc. | Sohaila Ahmed Bahaa Eldein Mohamed Eldeweny ; Supervised Hosny Ibrahim Mohamed Mostafa , Ghada Mohamed Elsayed , Mohamed Abdelmooti Samra |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | الطفرة الجينية ام بى ال دبليو ٥١٥ ال/كى فى الاورام الميلودية التكاثرية |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Sohaila Ahmed Bahaa Eldein Mohamed Eldeweny , |
| Date of publication, distribution, etc. | 2021 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 68 P. : |
| Other physical details | charts , facsimiles ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (M.Sc.) - Cairo University - Faculty of Science - Department of Biotechnology |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Myeloproliferative neoplasms (MPNs) describe a group of diseases involving the bone marrow. Classical MPNs are subdivided into chronic myelogenous leukemia (CML), polycythemia vera (PV), essential thrombocythemia (ET) and primary myelofibrosis (PMF). These subdivisions are made according to the presence of Philadelphia chromosome. CML are always Philadelphia (BCR-ABL) positive while PV, ET, and PMF are always negative. JAK2 p.Val617Phe point mutation is the most associated mutation in BCR/ABL negative MPNs. The frequency of JAK2 p.Val617Phe is 90-95% in PV patients, 50%-60% in ET, and 40-50% in patients with PMF. Studies on MPL gene revealed a gain of function mutations in JAK2 p.Val617Phe negative myeloproliferative neoplasms (MPNs). MPL p. W515L/K mutations are the most common across all mutations in MPL gene. The prevalence of these mutations over the Egyptian population is not clear enough. In this study we have investigated the frequency of MPL p.W515L/K and JAK2 p.Val617Phe mutations in 60 patients with MPNs using ARMS technique. BCR/ABL positive patients were excluded from the study. All patients were referred to the outpatient clinic of Nasser Institute hospital Cairo, Egypt. The study was carried out between February 2016 and January 2018. The diagnosis of MPNs was based on the World Health Organization criteria 2016 revision. Median age was 51 years (22-73). Splenomegaly was found in ET patients with higher frequency. JAK2 p.Val617Phe mutation was detected in 28 (46.7%) patients with no significant difference between the three groups, p = 0.143. All patients were negative for both mutations of the MPL p.W515L and MPL p.W515K |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | JAK2 p. Val617Phe |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | MPL p. W515L/K |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | MPNs |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Ghada Mohamed Elsayed , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Hosny Ibrahim Mohamed Mostafa , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Mohamed Abdelmooti Samra , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Shimaa |
| Reviser | Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.12.25.M.Sc.2021.So.M | 01010110083081000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.12.25.M.Sc.2021.So.M | 01020110083081000 | 22.09.2023 | CD - Rom | 83081.CD |