The effect of mesenchymal stem cells, with and without Melatonin, on the islets of Langerhans of induced diabetic adult male albino rat : (Record no. 80458)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 03472cam a2200349 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223032722.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 210331s2021 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.11.02.Ph.D.2021.Re.E |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Reda Ibrahim Abdalmohaimen Amer |
| 245 14 - TITLE STATEMENT | |
| Title | The effect of mesenchymal stem cells, with and without Melatonin, on the islets of Langerhans of induced diabetic adult male albino rat : |
| Remainder of title | Histological, immunohistochemical and fluorescent study / |
| Statement of responsibility, etc. | Reda Ibrahim Abdalmohaimen Amer ; Supervised Hoda Mahmoud Elaasar , Laila Ahmed Rashed , Abir Oueida Elsadik |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | دراسة هستولوجية: هستوكيميائية مناعية و مستشعة : |
| Remainder of title | تأثيرالخلايا الجذعية الوسيطة: مع وبدون الملاتونين: على جزر لانجرهانز فى مرض السكرى المستحث في ذكور الفئران البيضاء البالغة |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Reda Ibrahim Abdalmohaimen Amer , |
| Date of publication, distribution, etc. | 2021 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 118 P . : |
| Other physical details | charts , facsmilies ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Anatomy |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Diabetes is prevailing everywhere and adversely affecting the lives of individuals.Treatment of diabetes using insulin administration, oral antidiabetic drugs, whole pancreas and islets of Langerhans transplantation faced considerable limitations. Mesenchymal Stem cells (MSCs) inspired medical research with a promising new era in the treatment of DM having an advantage of easy short operation with minimal invasiveness of patients. Objective: To compare the effects of bone marrow MSCs and adipose tissue MSCs on the islets of Langerhans in diabetic rats, detect the enhancing role of melatonin (MT) on MSCs and elicit the mechanisms that induce islet cell regeneration.Material and methods: Sixty adult male albino rats were divided into six equal groups: group I (Control) received nothing, the remaining fifty were given a single dose of STZ of 50 mg/kg intraperitoneally, diagnosed diabetic by blood glucose higher than 220 mg/dl and were divided into: group II (STZ) received nothing, group III received a single intravenous injection of BM-MSCs, group IV received a single intravenous injection of AD-MSCs, group V received a single intravenous injection of MT pretreated BM-MSCs, group VI received a single intravenous injection of MT pretreated AD-MSCs. Results: AD-MSCs were significantly better compared to BM-MSCs in improving body weight, blood glucose, fasting serum insulin, IL-17, IL-10, area percent of PKH labelled MSCs, PCNA positive islets cells nuclei, Caspase-3 immuno-expression, PDX1 gene expression, Glut2 gene expression. MT pretreated MSCs gave significantly better results compared to untreated ones.Conclusion: MSCs could be a promising treatment of DM. MT pretreated AD-MSCs were the best in preservation and regeneration of the islet of Langerhans of the pancreas. |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Diabetes |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Islets of Langerhans |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Mesenchymal stem cells |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Abir Oueida Elsadik , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Hoda Mahmoud Elaasar , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Laila Ahmed Rashed , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Amira |
| Reviser | Cataloger |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.11.02.Ph.D.2021.Re.E | 01010110083111000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.11.02.Ph.D.2021.Re.E | 01020110083111000 | 22.09.2023 | CD - Rom | 83111.CD |