Efficacy, safety and cost effectiveness of metronomic low dose versus intermittent high dose capecitabine in metastatic breast cancer patients / (Record no. 80683)
[ view plain ]
| 000 -LEADER | |
|---|---|
| fixed length control field | 02976cam a2200349 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223032729.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 210417s2021 ua d f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.11.23.Ph.D.2021.Ha.E |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Hala Mostafa Abdelazim Elsebaie |
| 245 10 - TITLE STATEMENT | |
| Title | Efficacy, safety and cost effectiveness of metronomic low dose versus intermittent high dose capecitabine in metastatic breast cancer patients / |
| Statement of responsibility, etc. | Hala Mostafa Abdelazim Elsebaie ; Supervised Noha Yehia Abdou Ibrahim , Wael Samir Makkar , Shaimaa Farouk Lasheen |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | فعالية و سلامة و فعالية التكلفة من استخدام جرعة منخفضة مستمرة من عقار الكيبسيتابين فى مرضى سرطان الثدى المنتشر مقابل جرعة عالية متقطعة |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Hala Mostafa Abdelazim Elsebaie , |
| Date of publication, distribution, etc. | 2021 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 104 P. : |
| Other physical details | charts , facsimiles ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Oncology (Clinical) |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | We studied 51 patients in the period randomized to two arms of chemotherapy metronomic chemotherapy with Capecitabine versus intermittent Capecitabine as maintenance therapy following first-line Capecitabine plus Docetaxel chemotherapy in treatment of HER2-negative metastatic breast cancer. We had one patient died during initial phase as complication of uncontrolled diabetes. After ending the initial phase of treatment 48 patient randomized in the two arms of maintenance treatment. Regarding the descriptive data there was no statistically significant difference between the two arms except age and menopausal state, age (P value= 0.018) and menopausal state (P value= 0.015). Responding cases remained higher in continuous capecitabine (95.0% versus 78.9%) with no significant difference between both groups (p value = 0.061). Regarding toxicity, we assessed for toxicity every cycle and we did not find significant difference between groups after any cycle. However, there was significant difference between both arm regarding the grade III and IV toxicities, which was significantly higher in the intermittent capecitabine arm. Overall response rate was 60% in the intermittent capecitabine arm while it was 73.1% in the continuous capecitabine arm, respectively while Clinical benefit rate (CBR) was 64% in the intermittent capecitabine and it was 73.1% in the continuous capecitabine arm |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Breast cancer |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Capecitabine |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Clinical benefit rate (CBR) |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Noha Yehia Abdou Ibrahim , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Shaimaa Farouk Lasheen , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Wael Samir Makkar , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Shimaa |
| Reviser | Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.11.23.Ph.D.2021.Ha.E | 01010110083279000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.11.23.Ph.D.2021.Ha.E | 01020110083279000 | 22.09.2023 | CD - Rom | 83279.CD |