Circulating MicroRNAs as a prognostic biomarker predicting clinical outcome in breast cancer / (رقم التسجيلة. 81177)
[ عرض عادي ]
| 000 -LEADER | |
|---|---|
| fixed length control field | 02902cam a2200349 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223032745.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 210605s2021 ua d f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.12.02.Ph.D.2021.Ha.C |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Hadeer Hesham Abdelfattah Aly |
| 245 10 - TITLE STATEMENT | |
| Title | Circulating MicroRNAs as a prognostic biomarker predicting clinical outcome in breast cancer / |
| Statement of responsibility, etc. | Hadeer Hesham Abdelfattah Aly ; Supervised Hamed Abdelfatah Dabaon , Mohamed Aly Eldessouky , Neemat Mohamed Aly Kassem |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | الاحماض الميكرونووية ريبوزية الدوارة كعلامة بيولوجية نذيرة للتنبؤ بالنتيجة السريرية فى سرطان الثدى |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Hadeer Hesham Abdelfattah Aly , |
| Date of publication, distribution, etc. | 2021 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 112 P. : |
| Other physical details | charts ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (Ph.D.) - Cairo University - Faculty of Science - Department of Biochemistry |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Breast cancer is one of the most common cancers in women worldwide. Over 1.5 million women (25% of all women with cancer) are diagnosed with breast cancer every year throughout the world. Purpose & Methodology Quantitative assessment of plasma miRNA-34a & miRNA-125b expression was performed by qRT-PCR to predict outcome from neoadjuvant chemotherapy. Thirty nine newly diagnosed locally advanced breast cancer female patients with 10 age and sex matched healthy volunteers were included in the study. Results We performed ROC curve analysis to evaluate the diagnostic value for the miRNA-34a with AUCs = 0.995, cutoff point of 2.57 sensitivity 97.4%, specificity 100%, PPV 100%, NPV 83.3% and accuracy 97.7%.miRNA-125b had AUC = 0.68 and a cutoff point of 8.69 with sensitivity 66.7%, specificity 70.0%, PPV 90.6%, NPV 41.2% and accuracy 73.5%. miRNA-34a expression were significantly higher in breast cancer patients compared to controls with p value <0.001*. Also, miRNA-34a expression level was significantly higher in patients with progressive disease with P value =0.03*. However, miRNA-125b expression levels were insignificantly higher in responsive patients with p value = 0.2. Conclusion miRNAs are crucial candidates for novel molecular targeted therapies due to their capability to regulate numerous genes in molecular pathways. miRNA-34a can predict chemotherapeutic resistance associated with higher expression levels in non-responsive patients |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Breast cancer |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | DNA technology |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Gene expression |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Hamed Abdelfatah Dabaon , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Mohamed Aly Eldessouky , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Neemat Mohamed Aly Kassem , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Shimaa |
| Reviser | Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.12.02.Ph.D.2021.Ha.C | 01010110083596000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.12.02.Ph.D.2021.Ha.C | 01020110083596000 | 22.09.2023 | CD - Rom | 83596.CD |