Assessment of Immunomodulatory and anti-parasitic effect of bee venom-loaded pluronic F-127 nanoparticles on schistosomiasis infection in CD1 mice / (Record no. 81370)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 03100cam a2200349 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223032752.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 210623s2021 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | M.Sc |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.12.21.M.Sc.2021.Al.A |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Alaa Hussien Saleh Bashry |
| 245 10 - TITLE STATEMENT | |
| Title | Assessment of Immunomodulatory and anti-parasitic effect of bee venom-loaded pluronic F-127 nanoparticles on schistosomiasis infection in CD1 mice / |
| Statement of responsibility, etc. | Alaa Hussien Saleh Bashry ; Supervised Noha Ahmed Mahana , Abeer Mahmoud Badr , Ahmed Saeed Abdelmawgood |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | تقييم التأثير المناعى واالمضاد للطفليات لجزيئات البلوزونيك ف - 127النانونية المحملة بسم النحل على عدوى البلهارسيا فى فئران س د 1 |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Alaa Hussien Saleh Bashry , |
| Date of publication, distribution, etc. | 2021 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 107 P . : |
| Other physical details | charts , facsimiles ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (M.Sc.) - Cairo University - Faculty of Science - Department of Zoology |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Background: Honey-bee venom (BV) was reported to have an anti-schistosomiasis activity; however, it expands the hepatic granuloma size in high concentration. Aim: is to overcome the high-dose problems of BV by encapsulation inside pluronic F127 (F127) nanoparticles (NPs) and preserving the sustained release of BV. Methods: The treatment efficiency of free BV, F127 NPs or BV-loaded F127 NPs was investigated via in-vitro experiments and Shistosoma (S.) mansoni infected mice. After three weeks of treatment against S. mansoni either at the juvenile or adult stages. In addition, the parasitological, immunological and histopathological parameters were evaluated. Results: The obtained data showed a reduction in the total worm burden, oogram pattern and ova count for free BV, F127 NPs or BV-loaded F127 NPs compared to infected control. The immunomodulatory function was observed by stimulation of innate immune responses (IL-33) and T helper (Th)-1 immunity (TNF-Ü) when treated with loaded NPs while F127 NPs elicited the release of IL-33, TNF-Ü, IFN-Þ, IL-10 and IL-13 compared to infected control. All tested treatments induced a reduction in both the number and the diameter of granuloma, while BV-loaded NPs provoked newly-formed bile ductules. Both F127 NPs and BV-loaded NPs induced a significant decrease in liver fibrosis area percentage with respect to the infected control. Conclusion: Free BV has a limited effect on the larval stages of S. mansoni, while BV-loaded NPs and F127 NPs showed remarkable schistosomicidal effects with lower side effects |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Bee venom |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Pluronic F127 nanoparticles |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Schistosoma mansoni |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Abeer Mahmoud Badr , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Ahmed Saeed Abdelmawgood , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Noha Ahmed Mahana , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Amira |
| Reviser | Cataloger |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.12.21.M.Sc.2021.Al.A | 01010110083737000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.12.21.M.Sc.2021.Al.A | 01020110083737000 | 22.09.2023 | CD - Rom | 83737.CD |