Metformin as fetal hemoglobin inducer in non-transfusion-dependent thalassemia patients / (Record no. 81729)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 02687cam a2200349 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223032802.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 210815s2021 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | M.Sc |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.11.28.M.Sc.2021.Sh.M |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Shareef Karam Ali Easa |
| 245 10 - TITLE STATEMENT | |
| Title | Metformin as fetal hemoglobin inducer in non-transfusion-dependent thalassemia patients / |
| Statement of responsibility, etc. | Shareef Karam Ali Easa ; Supervised Mona Hassan Eltagui , Mona Kamal Elghamrawy , Mariam Saad Soliman |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | ميتفورمين" كمحفز للهيموغلوبين الجنينى فى مرضى أنيميا البحر الأبيض المتوسط غير المعتمدين على نقل الدم |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Shareef Karam Ali Easa , |
| Date of publication, distribution, etc. | 2021 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 103 P. : |
| Other physical details | charts , facsimiles ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Pediatrics |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Background: Metformin was reported as a potential fetal hemoglobin (HbF) inducing agent but its efficacy and safety in Non-Transfusion-Dependent Thalassemia (NTDT) patients were not fully studied. Objectives: A prospective interventional study aimed to study the effect of metformin on HbF change in NTDT and its role in ameliorating disease severity. Methods: Forty-two patients with established diagnosis of NTDT aged 12-23 years old were enrolled. They were receiving a stable dose of Hydroxyurea (HU) over the last 3 months. Inclusion criteria:- Confirmed diagnosis of NTDT based on hemoglobin Electrophoresis and/or high performance liquid Chromatography .- Age greater than or equal to 12 years of age.- Stable dose of HU over the last 3 months.- Serum creatinine less than or equals to 1.4 mg/dl . - Liver enzymes (ALT and AST) less than or equal to 3 times upper limits of normal .- Patients/ parents giving willingly informed consents Exclusion Criteria: - Simple or chronic red blood cell transfusion therapy in the last 3 months.- Patients with diabetes mellitus who are receiving other anti-diabetic medications.- Patients with chronic hypoxemic conditions associated with lactic acidosis, such as cardiovascular, renal, hepatic and pulmonary diseases |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | HbF inducers |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Metformin |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Non-transfusion dependent Thalassemia |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Mariam Saad Soliman , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Mona Hassan Eltagui , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Mona Kamal Elghamrawy , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Shimaa |
| Reviser | Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.11.28.M.Sc.2021.Sh.M | 01010110083919000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.11.28.M.Sc.2021.Sh.M | 01020110083919000 | 22.09.2023 | CD - Rom | 83919.CD |