Pharmacological study on the potential antineoplastic effects of thymoquinone and/or ellagic acid on HepG2 cells / (Record no. 81964)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 03083cam a2200349 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223032810.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 210904s2021 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | M.Sc |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.08.09.M.Sc.2021.Na.P |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Nada Abdelsalam Abdelsabour |
| 245 10 - TITLE STATEMENT | |
| Title | Pharmacological study on the potential antineoplastic effects of thymoquinone and/or ellagic acid on HepG2 cells / |
| Statement of responsibility, etc. | Nada Abdelsalam Abdelsabour ; Supervised Sanaa A. Kenawy , Gouda K. Helal , Nada A. Sallam |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | دراسة دوائية على الآثار المضادة للاورام المحتملة للثيموكوينون وحمض ايلاجيك منفردين أو مجتمعين على خلايا هيب جى- 2 |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Nada Abdelsalam Abdelsabour , |
| Date of publication, distribution, etc. | 2021 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 107 P. : |
| Other physical details | charts , facsimiles ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Pharmacology and Toxicology |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | In the 21st century, cancer is considered a major cause of death, specifically liver cancer hepatocellular carcinoma (HCC), which is the sixth most commonly diagnosed cancer and the fourth leading cause of cancer death worldwide in 2018. Sorafenib (SF) was recommended as the first-line treatment for advanced HCC as it is a small molecule target therapy but although it is an attractive and approved treatment for HCC but still needs researches to avoid its side effects. Therefore, the present study was constructed in order to explore the potential anti-cancer activity of a novel combination of plant-derived natural products consisting of thymoquinone (TQ) and Ellagic acid (EA) against HCC on Hep-G2 cells, comparing their effects to a standard drug SF and investigating any synergism between each of them and SF, in addition to investigating the underlying mechanisms for such modulation with emphasis on proliferation and apoptosis. The effect of SF, TQ, and EA were evaluated separately and in combination on HepG2. Cell viability, MAPK, AKT, GPC-3, and GSK3Ý activities. Moreover; PSTAT-3, VEGF, MMP-9, caspase-3, and Bcl2/BAX ratio, as well as NF-mB, TNF-Ü, and IL-6 were measured. Thymoquinone and ellagic acid combination showed significant cell inhibition, affecting all indicators of cell proliferation and angiogenesis in results near to SF results, in the same way, the addition of EA to SF increased its effectiveness. All these results give promising combinations to increase the effectiveness and by default decrease the side effects of SF or use TQ and EA combination instead of SF alone |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Ellagic acid (EA) |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Hepatocellular carcinoma (HCC) |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Sorafenib (SF) |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Gouda K. Helal , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Nada A. Sallam , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Sanaa A. Kenawy , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Shimaa |
| Reviser | Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.08.09.M.Sc.2021.Na.P | 01010110084079000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.08.09.M.Sc.2021.Na.P | 01020110084079000 | 22.09.2023 | CD - Rom | 84079.CD |