Assessment of the combined effect of acitretin and narrow band UVB on the clinical repigmentation and expression of E-cadherins in vitiligo lesions in comparison to narrow band UVB alone / (رقم التسجيلة. 82112)
[ عرض عادي ]
| 000 -LEADER | |
|---|---|
| fixed length control field | 03976cam a2200349 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223032814.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 210913s2021 ua d f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.11.10.Ph.D.2021.No.A |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Noha Adly Mohamed Saleh |
| 245 10 - TITLE STATEMENT | |
| Title | Assessment of the combined effect of acitretin and narrow band UVB on the clinical repigmentation and expression of E-cadherins in vitiligo lesions in comparison to narrow band UVB alone / |
| Statement of responsibility, etc. | Noha Adly Mohamed Saleh ; Supervised Shahira Abdelrahman Ramadan , Ola Mohammad Mohammad Abuzeid , Rana Fathy Hilal |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | تقييم التأثير المشترك لاستخدام الاسيترتين مع الأشعة فوق البنفسجية(ب) ضيقة النطاق على إعادة التصبغ الاكلينيكي والتعبير عن الاي كادهرين في آفات البهاق بالمقارنة مع الأشعة فوق البنفسجية ضيقة النطاق وحدها |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Noha Adly Mohamed Saleh , |
| Date of publication, distribution, etc. | 2021 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 177 P. : |
| Other physical details | charts ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (Ph.D.) - Cairo University - Faculty of Medicin - Department of Dermatology and Venerology |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Background:Absent or discontinuously distributedE-cadherin across melanocyte membranes has been linked to the pathogenesis of vitiligo. Narrowband UVB (NB-UVB) is a well-known treatment modality for vitiligo thatinduces re-pigmentation by different mechansims.Topical retinoic acid in combination with topical steroids has been tried before in the treatment of vitiligo andshowed better results than topical steroids alone.Retinoic acid was found to increase cell{u2013}cell adhesion through the recruitment of cytoplasmic adhesion molecules to the cell membraneand increases the stabilization of the Ý-catenin/E-cadherin complex in the cell membrane. Aim of the study:To evaluate and compare the clinical efficacy and safety of combining systemic retinoids (Acitretin) withNB-UVB (Re-NB-UVB) against NB-UVB alone in the treatment of vitiligo and to study their effect on the expression of E-cadherin in vitiligo skin. Patients and methods:This pilot study was conducted on 20 vitiligo patients and 20 controls.10 patients received NB-UVB and 10 patients receivedAcitretin at a dose (0.3 mg/kg/day) combined with NB-UVB. Both groups received 48 sessions (three times per week) of NB-UVB. Skin biopsies (lesional and perilesional) were taken at baseline and once pigmentationoccured. Skin biopsies were preserved in formalin (10%). For clinical evaluation, VASI and VIDA scores were performed before and after treatment. All biopsies from patients and controls were stained immunohistochemically by anti E-cadherin antibody. The expression of E-cadherin in skin biopsies was assessed in all layers of the epidermis in the form of intensity, pattern and distribution. Results: Before treatment, lesional and perilesional skin showed significantly lower intensity in E-cadherin expression in comparison to control skin (p < 0.0001 and 0.0019) respectively. The focal pattern was found more frequent in lesional and perilesional biopsiescompared to control (p<0.0001and 0.0471) respectively. Absent E-cadherin expression in the granular layer was found onlyin lesional and perilesional biopsies (p =0.0067 and 0.017) respectively. There was a significant negative correlation between E-cadherin intensity in the perilesional skin and disease duration (r= -0.581, p= 0.007) |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Acitretin |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Band UVB |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | E-cadherins |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Ola Mohammad Mohammad Abuzeid , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Rana Fathy Hilal , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Shahira Abdelrahman Ramadan , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Shimaa |
| Reviser | Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.11.10.Ph.D.2021.No.A | 01010110084169000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.11.10.Ph.D.2021.No.A | 01020110084169000 | 22.09.2023 | CD - Rom | 84169.CD |