Biochemical and molecular effects of some plant extracts on streptozotocin induced diabetic rats / (رقم التسجيلة. 83043)
[ عرض عادي ]
| 000 -LEADER | |
|---|---|
| fixed length control field | 03481cam a2200349 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223032844.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 211108s2021 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.12.02.Ph.D.2021.Ay.B |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Aya Abdelaziz Hanafey Mahmoud |
| 245 10 - TITLE STATEMENT | |
| Title | Biochemical and molecular effects of some plant extracts on streptozotocin induced diabetic rats / |
| Statement of responsibility, etc. | Aya Abdelaziz Hanafey Mahmoud ; Supervised Mohamed Ali Eldesouky , Doaa Samir Salah Eldin , Khairy Abdelmoneim Ibrahim |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | التأثيرات الكيميائية الحيوية والجزيئية لبعض مستخلصات النباتات على الجرذان المصابة بمرض السكرى المستحث بالستربتوزوتوسين |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Aya Abdelaziz Hanafey Mahmoud , |
| Date of publication, distribution, etc. | 2021 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 144 P. : |
| Other physical details | charts , facsimiles ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (Ph.D.) - Cairo University - Faculty of Science - Department of Biochemistry |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Study objective: The aim of the study is to assess the effect of aqueous extract of Pterocarpus santalinus heart wood and Brassica nigra seeds on amelioration of type 2 diabetes mellitus and evaluate the roles of these extracts on recover of diabetic nephropathy and diabetic liver injury in streptozotocin induced diabetic rats. The study is include 24 adult male albino rats and were divided into four groups, each group contain 6 animals. Group 1 served as control group. For induction of diabetes rats were received STZ (65 mg/kg body weight). After STZ induction the remaining three groups were split as follow: group 2 served as diabetic untreated group, group 3 served as diabetic group treated with aqueous Pterocarpus santalinus extract and group 4 served as diabetic group treated with aqueous Brassica nigra extract. Results: STZ administration produced significant up-regulation in the mRNA of Thioredoxininteracting protein (TXNIP), The Nod-like receptor protein 3(NLRP3) inflammasome and Apoptosis-enhancing nuclease (AEN). Also STZ administration produced significant increase in serum glucose, HbA1c, Homeostatic Model Assessment insulin resistance (HOMA-IR), lipids, creatinine, urea, ALT and AST levels; also, significant decrease in insulin, Homeostatic Model Assessment insulin sensitivity (HOMA-IS), Quantitative Insulin Sensitivity Check Index (QUICKI) and HDL levels. The effects of aqueous extracts of pterocarpus santalinus wood and Brassica nigra seeds were significant down-regulated the mRNA of TXNIP, NLRP3 and AEN. Also the results of this study showed that after treatment by aqueous of Pterocarpus santalinus wood and Brassica nigra seeds there were significant decreased in serum levels of glucose, HbA1c, lipids, creatinine, urea, ALT and AST as well as significant increase in insulin, Homeostatic Model Assessment insulin sensitivity (HOMA-IS), Quantitative Insulin Sensitivity Check Index (QUICKI) and HDL levels |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Brassica nigra seeds |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Pterocarpus santalinus heart wood |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Type 2 diabetes mellitus |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Doaa Samir Salah Eldin , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Khairy Abdelmoneim Ibrahim , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Mohamed Ali Eldesouky , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Shimaa |
| Reviser | Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.12.02.Ph.D.2021.Ay.B | 01010110084664000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.12.02.Ph.D.2021.Ay.B | 01020110084664000 | 22.09.2023 | CD - Rom | 84664.CD |