Cardiprotective effect of pentoxify lline in ischemic heart mediated via blockage of immune checkpoints / (رقم التسجيلة. 83130)
[ عرض عادي ]
| 000 -LEADER | |
|---|---|
| fixed length control field | 03067cam a2200349 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223032847.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 211114s2021 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.12.02.Ph.D.2021.Ah.C |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Ahlam Mohamed Abdelaziz Mohamed |
| 245 10 - TITLE STATEMENT | |
| Title | Cardiprotective effect of pentoxify lline in ischemic heart mediated via blockage of immune checkpoints / |
| Statement of responsibility, etc. | Ahlam Mohamed Abdelaziz Mohamed ; Supervised Mohamed Ali Eldesouky , Ayman Elsayed Shafei Abouelaa , Mostafa Mahmoud Mohamed Elnakib |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | التأثير الوقائى للبنتوكسيفيلين لمرض نقص تروية القلب عن طريق إحداث صمت فى نقاط التفتيش المناعية |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Ahlam Mohamed Abdelaziz Mohamed , |
| Date of publication, distribution, etc. | 2021 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 162 P. : |
| Other physical details | charts , facsimiles ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (Ph.D.) - Cairo University - Faculty of Science - Department of Biochemistry |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | The regulation by immune checkpoints is able to prevent excessive tissue damage caused by ischemia/reperfusion (I/R); therefore, the study aims to investigate the behavior of phosphoprotein associated with glycosphingolipid-enriched microdomains 1 (PAG1) mRNA, miR-1206 and small nucleolar RNA host gene 14 (SNHG14) during I/R and intake of pentoxifylline (PTX) as a protective drug.The relative expression level of PAG1/miR- 1206/SNHG14 was determined by qRT-PCR. Cardiac tissue levels of cytotoxic T-lymphocyte associated antigen 4 (CTLA4) and PAG1 protein expression were determined by ELISA technique. The regulatory T cells were achieved by the flow cytometry. The results indicated that the relative expression of SNHG14 was significantly up regulated in I/R, but suppressed in PTX treated groups with enhancement of the relative expression level of miR-1206. The gene and protein expression of PAG1 were down regulated with effective doses of PTX.The results showed that PTX dose between 30 and 40 mg/kg suppressed the CTLA4 development significantly.The mean of the regulatory T cell in PTX protective groups was significantly reduced at (p < 0.001) in a comparison with I/R group. Spearman{u2019}s correlation analysis revealed a significant negative correlation between SNHG14 and miR-1206, while a significant positive correlation between SNHG14 and PAG1 in I/R heart tissue. Based on the obtained results it is concluded that miR-1206 and SNHG14 may be used as biomarkers with perfect sensitivity and specificity in I/R. Further of PTX also reduced cardiac tissue damage |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Ischemia reperfusion |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | MiR-1206 |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Pentoxifylline |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Ayman Elsayed Shafei Abouelaa , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Mohamed Ali Eldesouky , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Mostafa Mahmoud Mohamed Elnakib , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Shimaa |
| Reviser | Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.12.02.Ph.D.2021.Ah.C | 01010110084734000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.12.02.Ph.D.2021.Ah.C | 01020110084734000 | 22.09.2023 | CD - Rom | 84734.CD |