Biochemical study on three colored calyces of roselle (hibiscus sabdariffa L.) as anti-alzheimer disease / (Record no. 83854)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 03303cam a2200349 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223032909.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 220104s2021 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | M.Sc |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.12.02.M.Sc.2021.Sa.B |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Sayeda Abdelaziz Abdelfattah Elmeqanen |
| 245 10 - TITLE STATEMENT | |
| Title | Biochemical study on three colored calyces of roselle (hibiscus sabdariffa L.) as anti-alzheimer disease / |
| Statement of responsibility, etc. | Sayeda Abdelaziz Abdelfattah Elmeqanen ; Supervised Mohammed Ahmed Badawy , Mohammed Aly Eldesoky , Mansour Hamed Mohamed |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | دراسة كيميائية حيوية على ثلاث سبلات ملونة من الكركديه هيبسكس سابدريفا ل. - كمضاد لمرض ألزهايمر |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Sayeda Abdelaziz Abdelfattah Elmeqanen , |
| Date of publication, distribution, etc. | 2021 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 70 P. : |
| Other physical details | charts , fcsimiles ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (M.Sc.) - Cairo University - Faculty of Science - Department of Biochemistry |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Background: Ý-Amyloid1-42, the major constituent of amyloid plaques, was believed to play a central role in the neuropathology of Alzheimer{u2019}s disease (AD) according to the{u2018}{u2018}amyloid cascade hypothesis. Hibiscus sabdariffa L. commonly named as " Roselle " is a member of malvaceae family.The aim of the present study was to investigate the effect of three colored calyces from Hibiscus sabdariffa L. on amyloid beta (AÝ42) production in a human neuroglioma model. Material and methods: The preparation of the three colored calyces extracts was performed within two solvent systems.The total flavonoid and the antioxidant activity by DPPH radical scavenging assay was evaluated.The in-vitro biological study was performed in a human neuroglioma cell line (H4) expressing the double Swedish mutation (K670N/M671L) of the human amyloid precursor protein (APPsw) under the transcriptional control of the hamster prion protein promoter. In addition to, Notch-mediated Hes1-Luciferase reporter assay was also investigated.The anti-COX activity and MTT assay were also evaluated. Results: All extracts showed a good inhibitory activity against DPPH free radical.The total flavonoid was detected in the present study as traces. No toxicity was detected by standard MTT assay against H4 cells treated with Roselle extracts. No inhibition activity was also observed against cyclooxygenases (COX-1 and COX- 2) by concentrations up to 600 ng/mL. All the different Roselle extracts allowed to inhibit AÝ42 levels in the neuroglioma cell line. Conclusion: The white green calyces at hot aqueous ethanol extraction was detected to be the best calyces and extraction method for alteration of AÝ42 in a human neuroglioma model via functional modulation of Þ-secretase mediated APP processing pathway |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Alzheimer{u2019}s disease (AD) |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Amyloid-Ý peptide (AÝ) |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Hibiscus sabdariffa L. |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Mansour Hamed Mohamed , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Mohammed Ahmed Badawy , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Mohammed Aly Eldesoky , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Shimaa |
| Reviser | Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.12.02.M.Sc.2021.Sa.B | 01010110085199000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.12.02.M.Sc.2021.Sa.B | 01020110085199000 | 22.09.2023 | CD - Rom | 85199.CD |