Possible modulatory effect of tadalafil and bergapten on experimentally induced cognitive impairment in mice / (Record no. 83935)
[ view plain ]
| 000 -LEADER | |
|---|---|
| fixed length control field | 02894cam a2200337 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223032911.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 220110s2021 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | M.Sc |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.08.09.M.Sc.2021.Mo.P |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Mohamed Ahmed Mahmoud Salem |
| 245 10 - TITLE STATEMENT | |
| Title | Possible modulatory effect of tadalafil and bergapten on experimentally induced cognitive impairment in mice / |
| Statement of responsibility, etc. | Mohamed Ahmed Mahmoud Salem ; Supervised Nesrine Salah Eldine Elsayed , Suzan Mohamed Mansour |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | تأثير فاعلية التطبيع المحتمل لعقارى التادالافيل والبيرجابتين لاعتلال الادراك المستحدث تجريبيا فى الفئران |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Mohamed Ahmed Mahmoud Salem , |
| Date of publication, distribution, etc. | 2021 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 139 P . : |
| Other physical details | charts , facsmilies ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Toxicology and Biochemistry |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Sporadic Alzheimer{u2019}s disease (SAD) is a slowly progressive neurodegenerative disorder characterized by deposition of amyloid beta (AÝ) plaques, tau protein aggregation, impaired insulin signaling, and neuroinflammation. This study aimed to investigate the neuroprotective potential of tadalafil (TAD) and bergapten (BG) in SAD-induced cognitive impairment in mice. SAD was induced by a single intracerebroventricular injection of streptozotocin (STZ) (3 mg/kg). TAD or BG was administered intraperitoneally at doses of 20 and 25 mg/kg, respectively, 5 hours after STZ injection for 21 consecutive days. TAD and BG conceivably attenuated STZ-induced hippocampal insult, preserved neuronal integrity, and improved cognitive function in the Morris water maze and object recognition tests paralleled by reduced AÝ expression and phosphorylation of tau. Moreover, TAD and BG enhanced the protein expression of pAkt, pGSK-3Ý, beclin-1, and methylated protein phosphatase 2A (PP2A) and cyclin D1 gene expression and raised brain-derived neurotrophic factor immunoreactivity. In addition, both drugs boosted the hippocampal levels of cyclic guanosine monophosphate (cGMP), protein kinase G (PKG), WNT3A, and adenosine monophosphate-activated protein kinase coupled by reduced protein expression of Ý-catenin and mammalian target of rapamycin (mTOR). TAD and BG also halted neuroinflammation as evidenced by reduced IL-23 and IL-27 levels and NF-mB protein expression |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Bergapten |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Sporadic Alzheimer{u2019}s disease |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Tadalafil |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Nesrine Salah Eldine Elsayed , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Suzan Mohamed Mansour , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Amira |
| Reviser | Cataloger |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.08.09.M.Sc.2021.Mo.P | 01010110085249000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.08.09.M.Sc.2021.Mo.P | 01020110085249000 | 22.09.2023 | CD - Rom | 85249.CD |