The potential neuroprotective effect of a dipeptidyl peptidase-4 inhibitor and peganum harmala extract in an experimental model of Alzheimer{u2019}s disease / (Record no. 84186)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 03218cam a2200361 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223032919.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 220212s2022 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.08.09.Ph.D.2022.Ro.P |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Rofida Abdalla Saleh |
| 245 14 - TITLE STATEMENT | |
| Title | The potential neuroprotective effect of a dipeptidyl peptidase-4 inhibitor and peganum harmala extract in an experimental model of Alzheimer{u2019}s disease / |
| Statement of responsibility, etc. | Rofida Abdalla Saleh ; Supervised Dalaal Mostafa Abdallah , Hanan Salah Eldeen Elabhar , Muhammed Abdellatif Saad |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | القدرة الواقية للأعصاب لأحد مثبطى إنزيم ديبيبتيديلبيبتيديز-٤ وخلاصة السذب البرى فى نموذج تجريبي لمرض الزهايمر |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Rofida Abdalla Saleh , |
| Date of publication, distribution, etc. | 2022 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 139 P. : |
| Other physical details | charts , facsimiles ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department Pharmacology and Toxicology of |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Peganumharmala (Ph) is a folk medicinal herb used in the Sinai Peninsula (Egypt) as a remedy for central disorders. The main constituents, harmine and harmaline, have displayed therapeutic efficacy against Alzheimer{u2019}s disease (AD) owing to their anticholinesterase activity; however, the herb potential on sensitizing central insulin to combat AD remains to be clarified. The current study aimed to explore the anti-amnesic effects of the methanolic Ph seed extract through moderating insulin signaling cascade, and comparing the results to a well-established dipeptidyl-peptidase (DPP)-4 antidiabetic, saxagliptin (SAX), while expanding on its mechanism, as well. Rats were allocated into normal control (NC), NC receiving SAX or the extract per se, AD model induced by aluminum chloride (AlCl3; 50 mg/kg/day; i.p) for six consecutive weeks, and AD model co-administered with SAX (3mg/kg; p.o) or with methanolic standardized Ph seed extract (187.5 mg/kg; p.o) starting 2 weeks post AlCl3. Both treatments enhanced cognition appraised by Y-maze, novel object recognition test and Morris water maze tests and improved histopathological structures altered by AlCl3. Additionally, they heightened the hippocampal contents of glucagon-like peptide (GLP)-1 and insulin, but abated insulin receptor substrate-1 phosphorylation at serine 307 (pS307-IRS-1). Besides, the two agents increased phosphorylated Akt at serine 473 (pS473-Akt) and glucose transporter type (GLUT)4. They also curtailed the hippocampal content of beta amyloid (AÝ)42, glycogen synthase (GSK)-3Ý and phosphorylated tau. They also enhanced Nrf2, while reduced lipid peroxides and replenished glutathione |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | GLP |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Alzheimer{u2019}s disease |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Peganum harmala |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Saxagliptin |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Dalaal M. Abdallah , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Hanan S. Elabhar , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Muhammed A. Saad , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Shimaa |
| Reviser | Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.08.09.Ph.D.2022.Ro.P | 01010110085404000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.08.09.Ph.D.2022.Ro.P | 01020110085404000 | 22.09.2023 | CD - Rom | 85404.CD |