Impact of notch1 signaling pathway on clinical course of pediatric t-cell acute lymphoblastic leukemia / (رقم التسجيلة. 84372)
[ عرض عادي ]
| 000 -LEADER | |
|---|---|
| fixed length control field | 04062nam a2200409 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - أخر تعامل مع التسجيلة | |
| control field | 20260516142557.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 220228s2021 ua dh frm 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloguing agency | EG-GiCUC |
| Transcribing agency | EG-GiCUC |
| Language of cataloging | eng |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| Language code of summary or abstract | eng |
| -- | ara |
| 049 ## - Acquisition Source | |
| Acquisition Source | Deposite |
| 082 04 - DEWEY DECIMAL CLASSIFICATION NUMBER | |
| Classification number | 540 |
| 092 ## - LOCALLY ASSIGNED DEWEY CALL NUMBER (OCLC) | |
| Classification number | 540 |
| Edition number | 21 |
| 097 ## - Degree | |
| Degree | M.Sc |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Local Call Number | Cai01.12.25.M.Sc.2022.Ma.I |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Authority record control number or standard number | Manar Hesham Fouad, |
| Preparation | preparation. |
| 245 10 - TITLE STATEMENT | |
| Title | Impact of notch1 signaling pathway on clinical course of pediatric t-cell acute lymphoblastic leukemia / |
| Statement of responsibility, etc. | by Manar Hesham Fouad ; Supervised Prof.Dr.Mahfouz Ali Abdelaziz , Prof.Dr.Nashwa Nagy Elkhazragy. |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | تأثير مسار نوتش على خط السير الاكلينكي لمرض سرطان الدم اللميفاوي الحاد من نوع الخلية التائية فى الأطفال |
| 264 #0 - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE | |
| Date of production, publication, distribution, manufacture, or copyright notice | 2022 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 216 Pages : |
| Other physical details | charts , facsimiles ; |
| Dimensions | 30 cm+ |
| Accompanying material | CD |
| 336 ## - CONTENT TYPE | |
| Content type term | text |
| Source | rda content |
| 337 ## - MEDIA TYPE | |
| Media type term | Unmediated |
| Source | rdamedia |
| 338 ## - CARRIER TYPE | |
| Carrier type term | volume |
| Source | rdacarrier |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (M.Sc.) - Cairo University - Faculty of Science - Department of Organic Chemistry |
| 504 ## - BIBLIOGRAPHY, ETC. NOTE | |
| Bibliography, etc. note | Bibliography: pages 140-227. |
| 520 #3 - SUMMARY, ETC. | |
| Summary, etc. | Acute Lymphoblastic Leukemia (ALL) represents the most commonly diagnosed cancer in children. T-cell Acute Lymphoblastic Leukemia (T-cell ALL) accounts for around 10-15% of pediatric ALL cases and 25% of adult cases. Constitutive activation of Notch signaling pathway takes place, as a result of NOTCH1 activating mutations, in over 60 % of T-ALL cases. Despite the remarkable improvement that the world has witnessed over the last half-century in the prognosis of ALL, relapse is still a major challenge. Also, the increasing percentage of patients suffering from treatment-related toxicities or chemotherapeutic resistance and recurrence has indicated the inaccuracy of the currently used risk allocation schemes, which consequently explains the necessity of a more reliable assessment approach of the leukemic status. Consequently, a deeper understanding of T-ALL biology at the molecular level is urgently needed to facilitate the identification of novel diagnostic and prognostic biomarkers and therapeutic targets that can ultimately enable early detection, targeted therapy with minimal side effects, and hence a better prognosis. More attention has been paid towards investigating the direct and indirect regulatory roles that NOTCH1 plays in order to promote leukemogenesis. The oncogenic microRNA miR-21 has been implicated in several hematological malignancies and solid tumors. Its oncogenic role in T-ALL is being exhibited through targeting the tumorsuppressive programmed cell death protein 4 (PCDP4). Its aberrant expression has also been associated with a poor prognosis. On the other hand, miR-193b-3p, or miR-193b, is a wellcharacterized tumor-suppressive microRNA that is usually downregulated in a wide range of cancers. In T{u2010} cell acute lymphoblastic leukemia, miR{u2010} 193b{u2010} 3p was also found to be repressed, and its repression was negatively associated with the proto{u2010} oncogene MYB expression. Its downregulation was also found to be associated with unfavorable prognostic features. Although the Notch-regulated long non-coding RNA, LUNAR1, has been demonstrated to be among the most prominently dysregulated lncRNAs in T-ALL cases, the association of its expression levels in the peripheral blood of patients with the clinicopathological features and/or prognosis has not been assessed yet |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Issues CD | Issued also as CD |
| 546 ## - LANGUAGE NOTE | |
| Text Language | Text in English and abstract in Arabic & English. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Bioechnology |
| 653 #1 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | ALL |
| -- | MiR-21 |
| -- | NOTCH1 |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Mahfouz Ali Abdelaziz |
| Relator term | thesis advisor. |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Nashwa Nagy Elkhazragy |
| Relator term | thesis advisor. |
| 900 ## - Thesis Information | |
| Grant date | 01-01-2022 |
| Supervisory body | Mahfouz Ali Abdelaziz |
| -- | Nashwa Nagy Elkhazragy |
| Universities | Cairo University |
| Faculties | Faculty of Science |
| Department | Department of Biotechnology |
| 905 ## - Cataloger and Reviser Names | |
| Cataloger Name | Shimaa |
| Reviser Names | Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Home library | Current library | Date acquired | Inventory number | Full call number | Barcode | Date last seen | Effective from | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | 85504 | Cai01.12.25.M.Sc.2022.Ma.I | 01010110085504000 | 22.09.2023 | 22.09.2023 | Thesis | |
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | 13822081 | Cai01.12.25.M.Sc.2022.Ma.I | 01020110085504000 | 22.09.2023 | 22.09.2023 | CD - Rom | 85504.CD |