The predictive role of ÝIII-Tubulin and MicroRNA-200c in advanced breast cancer patients receiving taxanes therapy / (رقم التسجيلة. 84389)
[ عرض عادي ]
| 000 -LEADER | |
|---|---|
| fixed length control field | 05502cam a2200445 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - أخر تعامل مع التسجيلة | |
| control field | 20260516151333.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 220305s2021 ua dh frm 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloguing agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| Language code of summary or abstract | eng |
| -- | ara |
| 049 ## - Acquisition Source | |
| Acquisition Source | Deposite |
| 082 04 - DEWEY DECIMAL CLASSIFICATION NUMBER | |
| Classification number | 610 |
| 092 ## - LOCALLY ASSIGNED DEWEY CALL NUMBER (OCLC) | |
| Classification number | 610 |
| Edition number | 21 |
| 097 ## - Degree | |
| Degree | Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Local Call Number | Cai01.19.02.Ph.D.2021.Fa.P |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Authority record control number or standard number | Fatma Mahmoud Abdelwahed Mohamed, |
| Preparation | preparation. |
| 245 14 - TITLE STATEMENT | |
| Title | The predictive role of ÝIII-Tubulin and MicroRNA-200c in advanced breast cancer patients receiving taxanes therapy / |
| Statement of responsibility, etc. | by Fatma Mahmoud Abdelwahed Mohamed ; Supervised Prof.Dr. Nadia Iskandar Zakhary, Prof.Dr.Saad Mohamed Elgendy, Prof.Dr.Amany Abdelhameed Aboubakr. |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | الدور التنبؤى لبيتا 3 تيوبيولين والحمض الريبوزى الدقيق 200 س فى مرضى سرطان الثدى المتقدم تحت العلاج الكيميائى بعقارالتاكسانز |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | |
| 264 #0 - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE | |
| Date of production, publication, distribution, manufacture, or copyright notice | 2021. |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 190 Pages : |
| Other physical details | charts , facsimiles ; |
| Dimensions | 25cm+ |
| Accompanying material | CD. |
| 336 ## - CONTENT TYPE | |
| Content type term | text |
| Source | rda content |
| 337 ## - MEDIA TYPE | |
| Media type term | Unmediated |
| Source | rdamedia |
| 338 ## - CARRIER TYPE | |
| Carrier type term | volume |
| Source | rdacarrier |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (Ph.D.) - Cairo University - National Cancer Institute - Department of Cancer Biology |
| 504 ## - BIBLIOGRAPHY, ETC. NOTE | |
| Bibliography, etc. note | Bibliography: Pages 201-235. |
| 520 #3 - SUMMARY, ETC. | |
| Summary, etc. | Background: Locally advanced breast cancer (LABC) is a common clinical problem, particularly in Egypt.The overall survival of LABC remained depressing.Therefore, finding a good predictor for the efficacy of treatment has an important significance. Class ÝIII tubulin is an isotype of tubulin that has been associated with malignant transformation and cancer development.The miRNAs are small non-coding RNAs that play an important role in gene regulation of many biological processes.Objective: To evaluate the role of ÝIII-tubulin and miRNA-200c as predictor markers for the efficacy of neoadjuvant taxanes therapy in advanced breast cancer patients. Methods: One hundred and forty three female breast patients: 22 patients with benign breast diseases and 121 breast cancer patients receiving neoadjuvant taxane therapy divided to: 94 responder patients and 27 non responder patients were enrolled in the present study and paraffin sections were collected. Patients were followed up from date of first diagnosis till end of the study.The expression level of ÝIII tubulin protein was immunohistochemically evaluated and miRNA 200c was evaluated using real time PCR. Results were correlated with response to neoadjuvant taxanes therapy. Results: The ÝIII tubulin protein was significantly higher in estrogen receptor (ER) negative and progesterone receptor (PR) negative breast cancer patients (P< 0.011, P< 0.053; respectively). It was also observed to be significantly up regulated in triple negative and HER2 enriched ( non luminals) cases and down regulated in luminals cases (p< 0.023).The miRNA 200 c was significantly down regulated in patients responding to taxanes as compared with non responders P< 0.009 |
| 520 #3 - SUMMARY, ETC. | |
| Summary, etc. | يعد سرطان الثدي عند النساء هو أكثر أنواع السرطانات التي يتم تشخيصها بين النساء في مصر ، حيث يقدر بنحو 22038 (32.4٪) ، يليه سرطان الكبد (14.3٪).<br/>سرطان الثدي المتقدم هو حالة سريرية شائعة ، خاصة في البلدان النامية (30-60٪). يعتبرالتعامل مع سرطان الثدي المتقدم أمرًا صعبًا بالنسبة لأخصائيي الأورام بسبب النطاق الواسع للعروض التقديمية.<br/>اكتسب العلاج الكيميائي الذى يتم تناوله قبل اجراء العمليةنجاح كبير فى التعامل مع سرطان الثدي المتقدم على مدى العقود الثلاثة الماضية. أثبتت التاكسانات ، وتحديداً الدوسيتاكسيل والباكليتاكسيل ، فعاليتها في علاج سرطان الثدي ، إما كعوامل منفردة أو مجتمعة.<br/>تم تحديد الهدف الخلوي لباكليتاكسيل على أنه الوحدة الفرعية ب للتوبيولين في الأنابيب الدقيقة. يرتبط الدوسيتاكسيل بنفس الموقع مثل الباكليتاكسيل ، ولكن مع تقارب أكبر.<br/>معظم العلاجات المضادة للسرطان لها فعالية وسمية غير متوقعة. العلامة التنبؤية هي عامل يشير إلى الحساسية أو المقاومة لعلاج معين. لذلك فان العلامات التنبؤية مهمة في علم الأورام لأن السرطانات المختلفة تستجيب بشكل مختلف للعلاجات المختلفة |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Issues CD | Issued also as CD |
| 546 ## - LANGUAGE NOTE | |
| Text Language | Text in English and abstract in Arabic & English. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Breast - cancer |
| 653 #1 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Advanced breast cancer |
| -- | Estrogen receptor (ER) |
| -- | ÝIII tubulin |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Amany Abdelhameed Aboubakr |
| Relator term | thesis advisor. |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Nadia Iskandar Zakhary |
| Relator term | thesis advisor. |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Saad Mohamed Elgendy |
| Relator term | thesis advisor. |
| 900 ## - Thesis Information | |
| Grant date | 01-01-2021 |
| Supervisory body | Nadia Iskandar Zakhary |
| -- | Saad Mohamed Elgendy |
| -- | Amany Abdelhameed Aboubakr |
| Universities | Cairo University |
| Faculties | National Cancer Institute |
| Department | Department of in Cancer Biology |
| 905 ## - Cataloger and Reviser Names | |
| Cataloger Name | Shimaa |
| Reviser Names | Revisor |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Home library | Current library | Date acquired | Inventory number | Full call number | Barcode | Date last seen | Effective from | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | 85510 | Cai01.19.02.Ph.D.2021.Fa.P | 01010110085510000 | 22.09.2023 | 22.09.2023 | Thesis | |
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | 13823942 | Cai01.19.02.Ph.D.2021.Fa.P | 01020110085510000 | 22.09.2023 | 22.09.2023 | CD - Rom | 85510.CD |