Expression and polymorphism of long non-coding RNAs in colorectal cancer / (رقم التسجيلة. 84414)
[ عرض عادي ]
| 000 -LEADER | |
|---|---|
| fixed length control field | 03371nam a2200421 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - أخر تعامل مع التسجيلة | |
| control field | 20260516114337.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 220306s2021 ua dh frm 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloguing agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| Language code of summary or abstract | eng |
| -- | ara |
| 049 ## - Acquisition Source | |
| Acquisition Source | Deposit |
| 082 04 - DEWEY DECIMAL CLASSIFICATION NUMBER | |
| Classification number | 540 |
| 092 ## - LOCALLY ASSIGNED DEWEY CALL NUMBER (OCLC) | |
| Classification number | 540 |
| Edition number | 21 |
| 097 ## - Degree | |
| Degree | Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Local Call Number | Cai01.12.02.Ph.D.2021.Ma.E. |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Authority record control number or standard number | Mahmod Morad Ragab Mohammed, |
| Preparation | preparation. |
| 245 10 - TITLE STATEMENT | |
| Title | Expression and polymorphism of long non-coding RNAs in colorectal cancer / |
| Statement of responsibility, etc. | Mahmod Morad Ragab Mohammed ; Supervised Prof.Dr. Ismail Abdelshafy Abdelhamid , Prof.Dr.Heba Mohammed Kamal Abdelhakeem , Prof.Dr.Olfat Gamil Shaker. |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | التعبير والتباين الجينى للأحماض النووية الريبوزية الطويبة غير المشفرة فى سرطان القولون والمستقيم |
| 264 #0 - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE | |
| Date of production, publication, distribution, manufacture, or copyright notice | 2021 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 84 Pages : |
| Other physical details | charts , facsimiles ; |
| Dimensions | 25cm+ |
| Accompanying material | CD |
| 336 ## - CONTENT TYPE | |
| Content type term | text |
| Source | rda content |
| 337 ## - MEDIA TYPE | |
| Media type term | Unmediated |
| Source | rdamedia |
| 338 ## - CARRIER TYPE | |
| Carrier type term | volume |
| Source | rdacarrier |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis ( Ph.D.) - Cairo University - Faculty of Science - Department of Biochemistry |
| 504 ## - BIBLIOGRAPHY, ETC. NOTE | |
| Bibliography, etc. note | Bibliography: pages 115-137. |
| 520 #3 - SUMMARY, ETC. | |
| Summary, etc. | Background: Colorectal cancer (CRC) is a complex disease that develops as a consequence of both genetic and environmental risk factors. Diet, smoking and drinking habits are among environmental factors frequently associated with CRC risk. Aim of work:The present study aims to conduct a clinical biochemical study that aids in the investigation of some non-coding RNA expressions and polymorphisms (including long non-coding RNAs and miRNAs) namely, Plasmacytoma Variant Translocation-1 (PVT-1) and miR-186 in an attempt to provide new noninvasive diagnostic biomarkers for CRC of the Egyptian patients. Patients and methods: Eighty CRC studies and thirty healthy controls were included. Laboratory and pathological investigations were assessed. Serum miR-186 and long non-coding PVT-1 was measured as well as genotype for PVT-1 rs13255292. Results: The CRC patients had a mean age of 50.91±12.0. The mean serum miR-186 level in CRC patients (1.38±0.21) was significantly higher than in the control (0.93±0.1) (p=0.0001). The PVT-1 level in CRC patients was (5.91±0.25) significantly higher than control (1.1±0.2) (p=0.001). The PVT-1/ rs13255292 genotype CT was significantly higher compared to the control group. The T allele was highly significant with a p-value of 0.008 in the CRC patient group with respect to the control. Conclusion: miR-186, long noncoding PVT-1 as well as PVT-1 the T allele may be considered as genetic markers for CRC susceptibility |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Issues CD | Issued also as CD |
| 546 ## - LANGUAGE NOTE | |
| Text Language | Text in English and abstract in Arabic & English. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Biochemistry |
| 653 ## - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Colorectal Cancer (CRC) |
| -- | Long non-coding RNAs (lncRNAs) |
| -- | MicroRNAs (miRNAs) |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Heba Mohammed Kamal Abdelhakeem |
| Relator term | thesis advisor. |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Ismail Abd Elshafy Abd Elhamid |
| Relator term | thesis advisor. |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Olfat Gamil Shaker |
| Relator term | thesis advisor. |
| 900 ## - Thesis Information | |
| Grant date | 01-01-2022 |
| Supervisory body | Ismail Abdelshafy Abdelhamid |
| -- | Heba Mohammed Kamal Abdelhakeem |
| -- | Olfat Gamil Shaker |
| Universities | Cairo University |
| Faculties | Faculty of Science |
| Department | Department of Biochemistry |
| 905 ## - Cataloger and Reviser Names | |
| Cataloger Name | Shimaa |
| Reviser Names | Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Home library | Current library | Date acquired | Inventory number | Full call number | Barcode | Date last seen | Effective from | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | 85489 | Cai01.12.02.Ph.D.2021.Ma.E. | 01010110085489000 | 22.09.2023 | 22.09.2023 | Thesis | |
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | 13824752 | Cai01.12.02.Ph.D.2021.Ma.E. | 01020110085489000 | 22.09.2023 | 22.09.2023 | CD - Rom | 85489.CD |