Evaluation of potential effects of anti-gout drug, zyloric on development of offspring of albino rats during lactation / (رقم التسجيلة. 84432)
[ عرض عادي ]
| 000 -LEADER | |
|---|---|
| fixed length control field | 07176nam a2200433 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - أخر تعامل مع التسجيلة | |
| control field | 20260517134455.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 220308s2022 ua dh frm 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloguing agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| Language code of summary or abstract | eng |
| -- | ara |
| 049 ## - Acquisition Source | |
| Acquisition Source | Deposit |
| 082 04 - DEWEY DECIMAL CLASSIFICATION NUMBER | |
| Classification number | 540 |
| 092 ## - LOCALLY ASSIGNED DEWEY CALL NUMBER (OCLC) | |
| Classification number | 540 |
| Edition number | 21 |
| 097 ## - Degree | |
| Degree | M.Sc |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Local Call Number | Cai01.12.25.M.Sc.2022.Ar.E |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Authority record control number or standard number | Areej Magdy Sultan Mohamed, |
| Preparation | preparation. |
| 245 10 - TITLE STATEMENT | |
| Title | Evaluation of potential effects of anti-gout drug, zyloric on development of offspring of albino rats during lactation / |
| Statement of responsibility, etc. | by Areej Magdy Sultan Mohamed ; Supervised Prof.Dr. Ahmed Farag , Prof.Dr.Abdelwahab Elghareeb , Prof.Dr.Heba Ali Abdelrahman. |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | تقييم التأثيرات المحتملة لعقار الزيلوريك المضاد للنقرس على نمو ولائد الجرزان أثناء الرضاعة |
| 264 #0 - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE | |
| Date of production, publication, distribution, manufacture, or copyright notice | 2022 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 71 P. : |
| Other physical details | charts , facsimiles ; |
| Dimensions | 25cm+ |
| Accompanying material | CD |
| 336 ## - CONTENT TYPE | |
| Content type term | text |
| Source | rda content |
| 337 ## - MEDIA TYPE | |
| Media type term | Unmediated |
| Source | rdamedia |
| 338 ## - CARRIER TYPE | |
| Carrier type term | volume |
| Source | rdacarrier |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (M.Sc.) - Cairo University - Faculty of Science - Department of Biotechnology |
| 504 ## - BIBLIOGRAPHY, ETC. NOTE | |
| Bibliography, etc. note | Bibliography: Pages 78-95. |
| 520 #3 - SUMMARY, ETC. | |
| Summary, etc. | Lactation, secretion and yielding of milk by females after giving birth. The milk produced by the mammary glands, which are contained within the breasts. The breasts, unlike most of the other organs, continue to increase in size after childbirth. Although mammary growth begins during pregnancy under the influence of ovarian and placental hormones, and some milk formed, copious milk secretion sets in only after delivery. Since lactation ensues after a premature birth, it would appear that milk production held back during pregnancy. The mechanism by which this inhibitory effect brought about, or by which lactation initiated at delivery, has long been the subject of an argument that revolves around the opposing actions of estrogen, progesterone, and prolactin. Relative to lactation; surprisingly little is known about the effects of glucocorticoid exposure on the developing fetus during lactation. One of the used corticosteroids in lactation is allopurinol. It is predominantly used for its anti-inflammatory effects, and treatment of gout. At present, no adequate data is available that as control to illustrate the safety use of allopurinol on the offspring during lactation, so in the present study we examine the offspring toxic effects of allopurinol on offspring if allopurinol was given orally at a recommended daily dose during lactation. Lactating albino rats (Rattus norvegicus) were administrated during lactation period with therapeutic dose. Offspring were examined after birth and evaluated for mortality rate, growth parameters, and morphological as well as histological study of liver, kidney and brain. During lactation, the morphological examination of the neonates showed that prednisone caused mild growth retardation represented by decrease in body weight, body length. Histopathological examination of the main vital organs liver, kidney and brain of neonates of the treated group on the seventh, fourteenth and twenty first days revealed that there was multiple hepatocytes exhibiting vacuolar degenerative changes with scattered necrotic cells and surrounding associated inflammatory cells in liver, in kidney shows Hepatic cell with pyknotic nuclei, fatty degeneration change, Central vein and erythroblasts were seen, brain shows increase in glomeruli, size within the Bowman's capsule, shrinkage glomeruli and degenerated tubules, Lymphatic infiltration invasion, karyolysis and degeneration of epithelial cells lining the proximal and distal tubules.It is recommended not to use allopurinol during lactation period as it transfer through milk to fetus because some fetal problems affect there brain, liver and kidney |
| 520 #3 - SUMMARY, ETC. | |
| Summary, etc. | من المدهش أنه لايُعرف سوى القليل عن تأثيرات التعرض للجلوكوكورتيكويد على الجنين النامي أثناء<br/>الرضاعة. أحد الستيرويدات القشرية المستخدمة في الإرضاع هو الوبيورينول. يتم استخدامه في الغالب<br/>لتأثيراته المضادة للالتهابات، وعلاج النقرس. في الوقت الحالي، لا توجد بيانات كافية متاحة كمراقبة<br/>لتوضيح سلامة استخدام الوبيورينول على النسل أثناء الرضاعة، لذلك في هذه الدراسة نقوم بفحص<br/>التأثيرات السامة للأولوبيورينول على النسل إذا تم إعطاء الوبيورينول عن طريق الفم بالجرعة اليومية<br/>الموصي بها أثناء الرضاعة. تم فحص النسل بعد الولادة وتقييم معدل الوفيات ومعايير النمو والدراسة<br/>المورفولوجيا والنسيجية للكبد والكلى والدماغ. أثناء الرضاعة، أظهر الفحص المورفولوجي لحديثي<br/>الولادة أن الوبيورينول تسبب في ازدياد نمو طفيف يتمثل في زيادة وزن الجسم وطول الجسم. أظهر<br/>الفحص النسيجي للأعضاء الحيوية الرئيسية الكبد والكلى والقشرة المخية للولائد من المجموعة المعالجة<br/>في اليوم السابع والرابع عشر والحادي والعشرين أن هناك العديد من خلايا الكبد تظهر تغيرات تنكسيه<br/>فجوية مع خلايا نخريه متناثرة وخلايا التهابية مرتبطة بها في الكبد، في تظهر الكلية خلية كبدية ذات نوى<br/>متثاقلة، زيادة في الكبيبات، والحجم داخل كبسولة بومان، وانكماش الكبيبات والأنابيب المتدهورة وغزو<br/>التسلل اللمفاوي، وانحلال النواة. نتائج القشرة المخية أظهرت تقلصاً في الخلايا العصبية الحمضية مع<br/>نوى متخمرة ودبق بؤري، وخلايا عصبية متحللة ذات نوى متثاقلة وأوعية دموية محتقنه ومتضخمة.<br/>يوصى بعدم استخدام الوبيورينول خلال فترة الرضاعة لأنه ينتقل عن طريق الحليب إلى الجنين لأن<br/>بعض مشاكل الجنين تؤثر فيه على والقشرة المخية والكبد والكلى |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Issues CD | Issued also as CD |
| 546 ## - LANGUAGE NOTE | |
| Text Language | Text in English and abstract in Arabic & English. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Biotechnology |
| 653 #1 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Albino rats |
| -- | Allopurinol |
| -- | Lactation |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Abdelwahab Elghareeb |
| Relator term | thesis advisor. |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Ahmed Farag |
| Relator term | thesis advisor. |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Heba Ali Abdelrahman |
| Relator term | thesis advisor. |
| 900 ## - Thesis Information | |
| Grant date | 01-01-2022 |
| Supervisory body | Ahmed Farag |
| -- | Abdelwahab Elghareeb |
| -- | Heba Ali Abdelrahman |
| Universities | Cairo Univsersity |
| Faculties | Faculty of Science |
| Department | Department of Chemistry |
| 905 ## - Cataloger and Reviser Names | |
| Cataloger Name | Shimaa |
| Reviser Names | Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Home library | Current library | Date acquired | Inventory number | Full call number | Barcode | Date last seen | Effective from | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | 85539 | Cai01.12.25.M.Sc.2022.Ar.E | 01010110085539000 | 22.09.2023 | 22.09.2023 | Thesis | |
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | 13825744 | Cai01.12.25.M.Sc.2022.Ar.E | 01020110085539000 | 22.09.2023 | 22.09.2023 | CD - Rom | 85539.CD |